抗阻训练改善2型糖尿病肾病风险患者的肾功能:一项随机对照试验

M. Moghadasi, Alireza Ostovar, Azita Eslami
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摘要

背景:尽管阻力训练(RT)在2型糖尿病的进展中具有预防作用,但其对糖尿病相关肾脏并发症的影响尚不清楚。目的:本研究旨在探讨RT治疗对2型糖尿病肾病高危患者肾功能的影响。方法:选取年龄52.8±7.3,体重指数(BMI) 27.4±3.1的中年2型糖尿病男性22例,随机分为对照组(CG: n = 12)和阻力训练组(RTG: n = 10)。受试者连续8周进行循环RT计划[每周3次,每次60分钟,6次练习,3组,重复8 - 15次,50 - 80%单次最多(1RM)]。8周前后分别测量临床参数,包括胰岛素样生长因子结合蛋白3 (IGFBP-3)、肾小球滤过率(eGFR)、空腹血糖、空腹胰岛素和胰岛素抵抗。结果:IGFBP-3水平在CG组显著升高(47.8%),而在RTG组保持不变。eGFR水平在CG组显著下降(16.7%),但在RTG组保持不变。与CG相比,RTG组的空腹血糖和胰岛素抵抗指数(HOMA-IR)水平显著降低(分别为16.7%和27.2%);然而,空腹胰岛素无显著变化(8.5%)。结论:结果提示,虽然RT并没有改善RTG的肾功能,但通过改善血糖控制,阻止了肾功能不全发展为糖尿病肾病,而CG的肾功能在训练期间恶化,可能与缺乏训练干预有关。需要更长的训练时间来进一步研究RT对糖尿病肾病发展的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Resistance Training Improved the Kidney Function of Type 2 Diabetic Patients with the Risk of Nephropathy: A Randomized Control Trial
Background: Despite the preventive role of resistance training (RT) in the progress of type 2 diabetes, its effects on diabetes-related kidney complications are still unknown. Objectives: This study was done to investigate the impacts of RT on kidney function of type 2 diabetic patients with the risk of nephropathy. Methods: Twenty-two middle-aged men with type 2 diabetes (age: 52.8 ± 7.3, body mass index (BMI): 27.4 ± 3.1) were randomly allocated into the control group (CG: n = 12) or resistance training group (RTG: n = 10). Subjects performed a circuit RT program [three times a week, 60 min/session, six exercises, three sets, 8 - 15 repetitions, 50 - 80% one-repetition maximum (1RM)] for eight consecutive weeks. Clinical parameters, including insulin-like growth factor-binding protein 3 (IGFBP-3), estimated glomerular filtration rate (eGFR), fasting glucose, fasting insulin, and insulin resistance, were measured before and after eight weeks. Results: IGFBP-3 levels significantly increased (47.8%) in CG, while they remained unchanged in the RTG. eGFR levels significantly decreased (16.7%) in the CG but remained unchanged in the RTG. Fasting blood glucose and insulin resistance index (HOMA-IR) levels significantly decreased (16.7% and 27.2%, respectively) in the RTG compared to the CG; however, for fasting insulin, no significant change was observed (8.5%). Conclusions: The results indicated that although RT did not improve the kidney function of the RTG, by improving the glycemic control, it prevented the development of renal dysfunction into diabetic nephropathy, while the renal dysfunction of the CG deteriorated over the training period, probably due to the lack of training intervention. Further studies with a longer training period are required to clarify the effects of RT on the development of diabetic nephropathy.
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