小剂量辐照增强小鼠脑抗氧化功能及其与抗坏血酸联合作用的基础研究

Radioisotopes Pub Date : 2020-02-15 DOI:10.3769/radioisotopes.69.45

T. Kataoka, Yuto Yunoki, Norie Kanzaki, K. Sasaoka, Yūsuke Kobashi, Tsuyoshi Ishida, K. Hanamoto, K. Yamaoka

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引用次数: 1

摘要

我们研究了低剂量x射线(0.1 ~ 2.0 Gy)照射后4 h ~ 7 d小鼠大脑抗氧化功能的变化特点，并与抗坏血酸(500 mg/kg体重)联合作用。结果显示，低剂量辐照主要表现为脂质过氧化水平降低，超氧化物歧化酶(SOD)活性和热休克蛋白(HSP)水平升高。此外，0.5 Gy辐照与抗坏血酸联合使用可显著降低脂质过氧化水平，提示抗氧化的联合作用。

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Basic Study on Enhancement of Antioxidant Function by Low-dose Irradiation in Mouse Brain and Its Combined Effect with Ascorbic Acid

We studied on the characteristics of changes in antioxidant function of mice brains at 4 h to 7 days after low-dose X-ray (0.1 to 2.0 Gy) irradiation, and the combination effect of this and administration of ascorbic acid (500 mg/kg body weight), an antioxidant enzyme. As a result, low-dose irradiation mostly showed decrease in lipid peroxide levels, increase in superoxide dismutase (SOD) activities and heat shock protein (HSP) levels. In addition, the combined use of 0.5 Gy irradiation with ascorbic acid administration showed a signiﬁcant decrease in lipid peroxide level, suggesting the combined effect of antioxidant.

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Radioisotopes

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