猴痘:一种正痘病毒的临床特征、过去和未来展望

S. Shukla, Naveen Rawat, Sarthak Rana, Vinod Rana, Chavi Mittal, Roshan Kumar, Prachi Sood
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引用次数: 2

摘要

就在国际社会开始从2019年冠状病毒病(COVID-19)可能传播引起的最初警报中恢复过来之际,出现了一些关于猴痘潜在传播的问题。尽管非洲部分地区传统上比世界其他地区更容易感染猴痘,但与2022年开始的疫情有关的大多数新病例报告发生在欧洲和西半球国家。尽管许多组织目前正在开展接触者追踪活动,但目前仍不清楚这次疫情的起源。猴痘病毒属于痘病毒科和正痘病毒属。继20世纪70年代在全球消灭天花之后,猴痘的消息在全球引起了广泛的担忧。通过接种天花病毒,个体能够对猴痘产生交叉免疫。在停止分发天花疫苗后,猴痘暴发的次数有所上升。2003年在美国发生的猴痘疫情是这种疾病第一次在媒体上得到广泛关注。尽管名为猴痘,但这种病毒并不是由猴子传播的。尽管许多不同种类的啮齿动物和其他小型哺乳动物被认为是猴痘病毒的原始宿主,但该病毒的真正谱系仍然是一个谜。引起猴痘的病毒最初是在猕猴身上发现的,这也是这种疾病首次被发现的地方。当猴痘确实从一个人传播到另一个人时,它通常是通过一个人的皮肤粘膜病变或通过他们排出的呼吸道飞沫传播的。然而,这种情况很少发生。然而,可以给予辅助治疗以减轻症状,并且在非常严重的病例中可以使用诸如替柯维明之类的药物。此时,对感染病毒的患者没有特异性治疗;然而,可以给予支持性治疗。这些治疗是否能成功减轻症状是有争议的,因为在这方面没有具体的指导方针可循。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical Features Present, Past & Future Prospective of Monkey Pox: A Orthopoxvirus
Some issues regarding the potential spread of monkeypox have arisen just as the international world is beginning to recover from the initial alarm that was caused by the probable spread of coronavirus disease 2019 (COVID-19). Despite the fact that parts of Africa have traditionally been more susceptible to monkeypox than other regions of the world, the majority of new cases that have been linked to the outbreak that began in 2022 have been reported in countries located in Europe and the western hemisphere. Despite the fact that a great number of organisations are working on contact-tracing activities at the moment, the origin of this outbreak is still unknown at this time. The monkeypox virus belongs to the family of viruses known as Poxviridae and the genus known as Orthopoxvirus. Following the eradication of smallpox across the globe in the 1970s, news of monkeypox caused widespread worry across the globe. Through vaccination with the smallpox virus, individuals were able to develop cross-immunity against monkeypox. After distribution of the smallpox vaccine was discontinued, the number of outbreaks of monkeypox rose. The monkeypox epidemic that occurred in the United States in 2003 was the first time that the disease gained extensive notice in the media. In spite of its name, the virus known as monkeypox is not transmitted by monkeys. Although a number of different kinds of rodents and other small mammals have been suggested as the primal hosts of the monkeypox virus, the virus's true lineage is still a mystery. The virus that causes monkeypox was first identified in macaque monkeys, which is where the disease was first seen. When monkeypox does transfer from one person to another, it often does so through a person's mucocutaneous lesions or through the respiratory droplets that they expel. However, this only happens very infrequently. However, supporting therapy can be given to reduce symptoms, and medications such tecovirimat may be administered in really severe cases. At this time, there is no specific treatment for patients who have infected the virus; however, supportive treatments can be given. It is debatable whether or not these treatments are successful in reducing symptoms because there are no concrete guidelines to follow in this regard.
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