Treatment outcome of primary Fibromyalgia Syndrome (FMS) using Duloxetine versus Pregabalin & Nortriptyline- An observational study

Introduction: The prevalence of FMS is about 2% as per ACR 2010 criteria. It is 5 times more common in women than in men. The etiology of FMS is presumptive and not clearly known as yet. Non-Pharmacological [Cognitive Behavioral Therapy (CBT)] and Pharmacological therapy is provided for mitigating somatic & psychological manifestations of FMS. Aim of study: To know the effectiveness of Duloxetine and Pregabalin+Nortriptyline on FMS for Kashmiri patients and compare their magnitude of effectiveness. Material and methods: It was 2 years observational study from July 2016 to June 2018. 50 patients fulfilling 2010 ACR classification criteria for FMS received the treatment. 26 patients received Duloxetine [Dose 20 mg-60 mg], 24 patients received Pregabalin [Dose 75 mg-150 mg] and Nortriptyline [Dose 25mg]. Results: Most of the parameters of FMS improved more in the Pregabalin+Nortriptyline group. However sadness improved more in the Duloxetine group. Conclusion: In addition to CBT [Cognitive Behavioral Therapy], Pharmaco Therapy is helpful in mitigating various parameters of Fibromyalgia syndrome to improve the quality of life of FMS patients.