与妇女生殖史有关的受孕产物的核型特征

I. Tkach, N. Huleyuk, D. Zastavna, G. Bezkorovaina, N. Helner, T. V. Fedushun, T. B. Snizhko, O. V. Benko
{"title":"与妇女生殖史有关的受孕产物的核型特征","authors":"I. Tkach, N. Huleyuk, D. Zastavna, G. Bezkorovaina, N. Helner, T. V. Fedushun, T. B. Snizhko, O. V. Benko","doi":"10.7124/feeo.v29.1425","DOIUrl":null,"url":null,"abstract":"Aim. The prognosis of the reproductive function of women with pregnancy loss is complex and partly based on the results of karyotyping of material of reproductive loss. We studied the features of the karyotype of material of EPL depending on the reproductive history of women with an emphasis on viable and non–viable karyotype abnormalities(KA). Methods. Banding cytogenetic and interphase mFISH with the centromeric probe panel for chromosomes 13, 14, 15, 16, 17, 18, 21, 22, X and Y were used. Results. Were examined 1734 cases of material EPL. Abnormal karyotype was set in 39.3% of cases. The frequency of KA is not significantly different in the material of EPL obtained from women with different reproductive history, namely: first pregnancy loss– 38.9% RPL – 38.2% and SPL – 41.0% (P> 0.05). In the group with RPL significantly more frequent non–viable KA and less viable KA, compared with a group of SPL namely 70.15% and 29.85% compared to 58.85% and 41.15% respectively(P<0.025). Conclusions. The contribution of different KA in genesis of the EPL depends on the reproductive history of women, namely women with RPL significantly increases the proportion of non–viable KA and reduced contribution viable KA compared with a group of SPL. \nKeywords: early reproductive loss, maternal reproductive history, karyotype abnormalities.","PeriodicalId":12181,"journal":{"name":"Faktori eksperimental'noi evolucii organizmiv","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Characteristic of the karyotype of products of conception depending on reproductive history of women\",\"authors\":\"I. Tkach, N. Huleyuk, D. Zastavna, G. Bezkorovaina, N. Helner, T. V. Fedushun, T. B. Snizhko, O. V. Benko\",\"doi\":\"10.7124/feeo.v29.1425\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aim. The prognosis of the reproductive function of women with pregnancy loss is complex and partly based on the results of karyotyping of material of reproductive loss. We studied the features of the karyotype of material of EPL depending on the reproductive history of women with an emphasis on viable and non–viable karyotype abnormalities(KA). Methods. Banding cytogenetic and interphase mFISH with the centromeric probe panel for chromosomes 13, 14, 15, 16, 17, 18, 21, 22, X and Y were used. Results. Were examined 1734 cases of material EPL. Abnormal karyotype was set in 39.3% of cases. The frequency of KA is not significantly different in the material of EPL obtained from women with different reproductive history, namely: first pregnancy loss– 38.9% RPL – 38.2% and SPL – 41.0% (P> 0.05). In the group with RPL significantly more frequent non–viable KA and less viable KA, compared with a group of SPL namely 70.15% and 29.85% compared to 58.85% and 41.15% respectively(P<0.025). Conclusions. The contribution of different KA in genesis of the EPL depends on the reproductive history of women, namely women with RPL significantly increases the proportion of non–viable KA and reduced contribution viable KA compared with a group of SPL. \\nKeywords: early reproductive loss, maternal reproductive history, karyotype abnormalities.\",\"PeriodicalId\":12181,\"journal\":{\"name\":\"Faktori eksperimental'noi evolucii organizmiv\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-08-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Faktori eksperimental'noi evolucii organizmiv\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7124/feeo.v29.1425\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Faktori eksperimental'noi evolucii organizmiv","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7124/feeo.v29.1425","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

的目标。妊娠丧失妇女生殖功能的预后是复杂的,部分基于生殖丧失材料的核型结果。我们研究了EPL材料的核型特征,这取决于妇女的生殖史,重点是活的和非活的核型异常(KA)。方法。用着丝粒探针板对染色体13、14、15、16、17、18、21、22、X和Y进行细胞遗传学和间期mFISH显带。结果。对1734例EPL材料进行了检查。39.3%的病例存在核型异常。不同生育史女性EPL材料中KA发生率无显著差异,分别为:首次妊娠丢失38.9%、RPL 38.2%和SPL 41.0% (P < 0.05)。与SPL组相比,RPL组无活菌KA和低活菌KA发生率分别为70.15%和29.85%和58.85%,显著高于SPL组(P<0.025)。结论。不同KA对EPL发生的贡献取决于女性的生殖史,即与一组SPL相比,RPL女性显著增加了无活KA的比例,减少了有活KA的贡献。关键词:早期生殖丧失,母体生殖史,核型异常。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characteristic of the karyotype of products of conception depending on reproductive history of women
Aim. The prognosis of the reproductive function of women with pregnancy loss is complex and partly based on the results of karyotyping of material of reproductive loss. We studied the features of the karyotype of material of EPL depending on the reproductive history of women with an emphasis on viable and non–viable karyotype abnormalities(KA). Methods. Banding cytogenetic and interphase mFISH with the centromeric probe panel for chromosomes 13, 14, 15, 16, 17, 18, 21, 22, X and Y were used. Results. Were examined 1734 cases of material EPL. Abnormal karyotype was set in 39.3% of cases. The frequency of KA is not significantly different in the material of EPL obtained from women with different reproductive history, namely: first pregnancy loss– 38.9% RPL – 38.2% and SPL – 41.0% (P> 0.05). In the group with RPL significantly more frequent non–viable KA and less viable KA, compared with a group of SPL namely 70.15% and 29.85% compared to 58.85% and 41.15% respectively(P<0.025). Conclusions. The contribution of different KA in genesis of the EPL depends on the reproductive history of women, namely women with RPL significantly increases the proportion of non–viable KA and reduced contribution viable KA compared with a group of SPL. Keywords: early reproductive loss, maternal reproductive history, karyotype abnormalities.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信