电纺丝明胶纳米纤维支架在组织工程中的应用

Katarina Virijević, Jelica Grujić, Milena Jovanović, Nikolina Kastratović, Ana Mirić, D. Nikolić, M. Zivanovic, N. Filipovic
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引用次数: 1

摘要

静电纺丝技术在组织工程领域,特别是生物医学领域应用广泛[1]。这个过程的概念是基于产生非织造纳米纤维。该方法包括高压电,它被施加到液体溶液和收集器上,收集器让溶液从喷嘴中挤出,形成射流。射流形成的纤维在静电力的影响下集中并沉积在收集器上。本研究的主要目的是制备微纳米级明胶支架,用于成功的伤口敷料。明胶可以模拟天然皮肤细胞外基质(ECM)的化学成分、物理结构和结构。然而,本研究的首要原则是静电纺丝工艺参数的优化。所使用的参数对获得合适的纤维用于进一步的细胞播种和细胞体外生长具有至关重要的作用。利用一系列不同的生物相容性聚合物和溶剂,在不同的静电纺丝环境下对溶液进行了测试,以生产微尺度纤维。用扫描电镜对支架进行分析,测定纤维直径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ELECTROSPUN GELATIN NANOFIBROUS SCAFFOLDS – APPLICATIONS IN TISSUE ENGINEERING
Electrospinning is highly used technique in the tissue engineering field, particularly in biomedical application [1]. The constricted concepts of this process are based on generate nonwoven nanofibers. The method involves high voltage electricity which is applied to the liquid solution and a collector, which lets the solution force out from a nozzle forming a jet. The jet formed fibers under influence of electrostatic forces concentrated and deposited these on the collector. Main objective of this study was to fabricate gelatin scaffolds with micro/nano-scale for successful wound dressing. Gelatin can mimic the chemical composition, physical structure and structure of the native skin extracellular matrix (ECM). However, the first and main principle in this study is the optimization of parameters of the electrospinning process. The used parameters have a crucial role in obtaining suitable fibers for further cell seeding and cell growth in vitro. With the use of series of various biocompatible polymers and solvents, solutions were tested in various electrospinning settings in order to produce microscale fibers. The scaffolds were analysed with scanning electron microscope images for fiber diameter measurement.
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