{"title":"抗羟基-3-甲基戊二酰辅酶引起的罕见色素尿症免疫抑制治疗还原酶(HMGCR)诱导的肌肉坏死:1例报告和文献复习","authors":"E. John, P. Kelly","doi":"10.37532/1758-4272.2021.16(7).207","DOIUrl":null,"url":null,"abstract":"Myositis and muscle necrosis can be associated with anti-HMGCR antibody in patients with prior HMG-CoA reductase exposure. There are isolated reports of muscle necrosis in patients with no prior history of statin exposure. We percent a case of severe muscle necrosis with no predisposing factors. Our patient had high anti-HMGCR antibody titers causing rhabdomyolysis, muscle necrosis requiring long-term immunosuppressive agents","PeriodicalId":13740,"journal":{"name":"International Journal of Clinical Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Rare cause of pigmenturia from anti-hydroxy-3-methylglutarylcoenzyme; A reductase (HMGCR) induced muscle necrosis treated withimmunosuppression: A Case Report and literature review\",\"authors\":\"E. John, P. Kelly\",\"doi\":\"10.37532/1758-4272.2021.16(7).207\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Myositis and muscle necrosis can be associated with anti-HMGCR antibody in patients with prior HMG-CoA reductase exposure. There are isolated reports of muscle necrosis in patients with no prior history of statin exposure. We percent a case of severe muscle necrosis with no predisposing factors. Our patient had high anti-HMGCR antibody titers causing rhabdomyolysis, muscle necrosis requiring long-term immunosuppressive agents\",\"PeriodicalId\":13740,\"journal\":{\"name\":\"International Journal of Clinical Rheumatology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Clinical Rheumatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37532/1758-4272.2021.16(7).207\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Clinical Rheumatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37532/1758-4272.2021.16(7).207","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Rare cause of pigmenturia from anti-hydroxy-3-methylglutarylcoenzyme; A reductase (HMGCR) induced muscle necrosis treated withimmunosuppression: A Case Report and literature review
Myositis and muscle necrosis can be associated with anti-HMGCR antibody in patients with prior HMG-CoA reductase exposure. There are isolated reports of muscle necrosis in patients with no prior history of statin exposure. We percent a case of severe muscle necrosis with no predisposing factors. Our patient had high anti-HMGCR antibody titers causing rhabdomyolysis, muscle necrosis requiring long-term immunosuppressive agents
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