https://researchopenworld.com/endocrine-disruptors-caused-faulty-hormonal-imprinting-focus-on-women/#

G. Csaba
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引用次数: 1

摘要

激素印记是一个生理过程,当激素受体和目标激素第一次相遇,围产期。这个过程是受体-激素复合物正常功能所必需的,并且对生命有效。然而,激素样分子也可以与发育中的受体结合,导致错误的印记及其后果:改变激素的结合,倾向于疾病,疾病的表现,扰乱生理激素调节。错误的印记也会产生终生的影响。工业的、公共的、营养的和医疗的内分泌干扰物是有缺陷的印记物,也是它们的变量,因为它们在人类环境中的数量正在急剧增长。错误的印迹也影响微粒体酶系统。许多在成年时表现出来的疾病可以推断为围产期激素印记的缺陷,妇女对药物的更高敏感性(更多的不良反应)可以用围产期事件来解释。内分泌干扰物的变异和数量的急剧增长可能会重新排列整个内分泌系统,这在未来可能是灾难性的,也可能是有益的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
https://researchopenworld.com/endocrine-disruptors-caused-faulty-hormonal-imprinting-focus-on-women/#
Hormonal imprinting is a physiological process, when hormone receptors and the target hormone meet in the first occasion, perinatally. This process is needed for the normal function of the receptor-hormone complex and valid for life. However, hormone-like molecules also can bind to the developing receptor causing faulty imprinting and its consequences: altered binding of hormones, inclination to diseases, manifestation of diseases, disturbing the physiological hormonal regulation. The faulty imprinting also has a lifelong effect. Industrial, communal, nutritional and medical endocrine disruptors are faulty imprinters and their variables as well, as amounts are enormously growing in the human environment. The faulty imprinting influences also the microsomal enzyme system. Numerous diseases, manifested at adult age can be deduced to perinatal faulty hormonal imprinting and the higher sensitivity of women to drugs (more adverse reactions) could be explained by perinatal events. The extremely growing variants and amount of endocrine disruptors could rearrange the whole endocrine system, which could be disastrous or useful alike in the future.
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