接受心脏手术的肝硬化患者:为什么不制定更具体的心脏-肝脏评分?

A. Morgante
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引用次数: 0

摘要

尽管术前肝硬化不包括在传统的风险评分中,但肝硬化,尤其是晚期肝硬化,一直对心脏手术患者的短期和中期最终结局有很大影响。与代谢综合征相关的非酒精性脂肪性肝病发病率的增加以及医学治疗的显著进步实际上增加了肝硬化患者进行心脏手术的可能性。迄今为止,Child-Pugh和MELD评分通常用于预测死亡率和术后肝失代偿,但另一方面,这两种传统的风险评分在评估接受心脏手术的肝病患者时存在一定的局限性。在这种情况下,一个具体的心脏-肝脏评分还没有被开发出来,试图勾勒出一个能够面对手术的病人的轮廓,因此,我们需要为每个病例采取可能的最佳策略。如果CP A级或低MELD评分(<11)的患者接受心脏手术,死亡率和发病率轻微增加,目前的技术水平建议对存在晚期肝病的手术想法特别谨慎。就心脏手术而言,在一些危及生命的病例中,心脏手术是唯一的治疗策略,无论如何,心脏病理的手术矫正并不能保证根据持续的肝功能障碍延长预期寿命。因此,本文将重点讨论在未来实现心脏-肝脏预后评分时应考虑的术前参数,以克服肝脏疾病对最终临床结果的影响相关的限制和困难。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cirrhotic Patients Undergoing Cardiac Surgery: Why Not to Develop a More Specific Heart-Liver Score?
Despite not included in the traditional risk scores before surgery, liver cirrhosis, especially in advanced stages, has always influenced strongly final outcome both on short and midterm in patients undergoing cardiac surgery. Growing incidence of non-alcoholic fatty liver disease interlinked with metabolic syndrome and significant advancements in medical therapy have actually increased the likelihood of cardiac surgery in cirrhotic patients. To date, Child-Pugh and MELD scores have been commonly used to predict mortality and postoperative hepatic decompensation, but on the other hand, both traditional risk scores show some limitations for evaluation of hepatopathic patients undergoing specifically cardiac surgery. In this context, a specific Heart-Liver score hasn’t been developed yet in the attempt to outline a patient profile able to face surgery, therefore addressing us to adopt the best strategy possible for each case. If CP class A or low MELD score (<11) patients tolerate cardiac surgery with a mild increase in mortality and morbidity, currently state of art recommends particular caution towards surgery idea in presence of advanced hepatic disease. As far as cardiac surgery represents the unique therapeutic strategy in several life-threatening cases, anyway surgical correction of cardiac pathology won’t guarantee an increased life expectancy in accordance with the persistent liver dysfunction. Hereby, this paper will focus on preoperative parameters that should be considered in the future realization of a Heart-Liver prognostic score for overcoming limitations and difficulties related to the impact of liver disease on final clinical outcome.
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