对照:将子宫内膜癌的分子亚型和组织型/分级整合为一个分类系统

IF 0.1 Q4 PATHOLOGY
M. Köbel
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引用次数: 0

摘要

Cancer Genome Atlas项目建立了4种子宫内膜癌分子亚型及其替代品(POLE突变、错配修复缺陷、p53异常和无特异性分子谱),引发了如何将这些亚型整合到传统的组织型/分级分类中的争论。与组织型/分级和分子亚型诊断相矛盾的具体问题将通过举例来讨论。组织型/等级和分子亚型的层次是相互依赖的。病理学家应致力于整合组织型/分级和分子亚型,以提供一个一致的和临床相关的诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Counterpoint: Integration of Molecular Subtype and Histotype/Grade Into One Classification System for Endometrial Carcinoma
Abstract The establishment of 4 endometrial carcinoma molecular subtypes by The Cancer Genome Atlas project and their surrogates (POLE mutated, mismatch repair–deficient, p53 abnormal, and no specific molecular profile) invigorated a debate on how to integrate these within the traditional histotype/grade classification. Specific issues of contradicting histotype/grade and molecular subtype diagnoses will be discussed with illustrated examples. The hierarchy of histotype/grade and molecular subtype is interdependent. Pathologists should aim to integrate histotypes/grades and molecular subtypes to provide one consistent and clinically relevant diagnosis.
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CiteScore
0.30
自引率
0.00%
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