印度蜂胶对实验性大鼠溃疡模型的抗溃疡和溃疡愈合作用

Iyyam Pillai, M. Kandaswamy, S. Subramanian
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引用次数: 18

摘要

蜂胶是一种树脂状的蜂箱产品,由工蜂从植物的各个部位收集而成。它在印度民间医学中被广泛用于治疗胃溃疡。采用乙醇和吲哚美辛致大鼠急性胃损伤模型,评价印度蜂胶对溃疡的预防和治疗作用。采用结扎幽门模型,评价蜂胶乙醇提取物对胃内容物体积、总酸度和pH的影响。与对照组相比,蜂胶提取物预处理的动物在乙醇和吲哚美辛诱导的溃疡模型中损伤指数均呈剂量依赖性降低。同样,蜂胶(300 mg/kg体重)治疗15天后,溃疡愈合过程有统计学意义的改善p <0.05。在结膜幽门模型中,观察到印度蜂胶提取物显示出抗分泌活性,导致胃液体积、总酸度和ph值显著减少。这些发现表明,印度蜂胶具有预防溃疡和治疗溃疡的双重特性,为蜂胶在传统医学体系中的应用提供了科学依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antiulcerogenic and ulcer healing effects of Indian propolis in experimental rat ulcer models
Propolis is a resinous hive product collected by worker bees from various parts of the plants. It is widely used in Indian folk medicine for the treatment of stomach ulcers. The preventive and curative effects of Indian propolis for ulcers were evaluated using models of acute gastric lesions induced by ethanol and indomethacin in rats. Moreover, the effects of ethanolic extract of propolis on gastric content volume, total acidity and pH, using the pylorus ligated model were also evaluated. Animals pretreated with propolis extract showed a significant reduction in lesion index in both ethanol and indomethacin induced ulcer models in a dose dependent manner when compared to the control group. Similarly, post-treatment with propolis (300 mg/kg body weight) for a period of 15 days revealed a statistically significant improvement in the ulcer healing process p <0.05. In the pylorus ligated model, it was observed that the Indian propolis extract displayed an antisecretory activity, which led to a significant reduction in the gastric juice volume, total acidity and pH. These findings indicate that Indian propolis displays both ulcer preventive and ulcer curative properties and provides a scientific rationale for the use of propolis in the traditional medicinal system.
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