用于噬菌体治疗药物有效递送的纳米乳液封装。

IF 1.5 4区生物学 Q4 BIOCHEMICAL RESEARCH METHODS

Biologicals Pub Date : 2023-11-09 DOI:10.1016/j.biologicals.2023.101725

Loushambam Samananda Singh

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引用次数: 0

摘要

抗生素耐药性已成为全球公共卫生关注的主要问题。噬菌体治疗被认为是治疗多重耐药细菌感染的替代抗生素。噬菌体治疗的发展面临着许多挑战，包括可持续噬菌体递送的药物配方。纳米乳液平台被认为是保持噬菌体功效、保质期和稳定性的最佳方法。包封噬菌体药物可确保噬菌体稳定地递送到靶点并融入系统。本文就噬菌体的纳米乳剂包封及其对噬菌体治疗的影响作一综述。

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Nano-emulsion encapsulation for the efficient delivery of bacteriophage therapeutics

Antibiotic resistance has become the major concern for global public health. Phage therapy is being considered as an alternative for antibiotics to treat the multidrug resistant bacterial infections. Bacteriophage therapeutic developments has faced many challenges, including the drug formulations for sustainable phage delivery. The nano-emulsion platform has been described as the best approach to retain phage efficacy, shelf life and stability. Encapsulated phage drugs ensure stable delivery of phages to the target site and integrate in the system. In this review, our main focus is on the nano-emulsion encapsulation of bacteriophages and its effects towards the phage therapeutic development.

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来源期刊

Biologicals 生物-生化研究方法

CiteScore

3.70

自引率

0.00%

发文量

审稿时长

48 days

期刊介绍： Biologicals provides a modern and multidisciplinary international forum for news, debate, and original research on all aspects of biologicals used in human and veterinary medicine. The journal publishes original papers, reviews, and letters relevant to the development, production, quality control, and standardization of biological derived from both novel and established biotechnologies. Special issues are produced to reflect topics of particular international interest and concern.Three types of papers are welcome: original research reports, short papers, and review articles. The journal will also publish comments and letters to the editor, book reviews, meeting reports and information on regulatory issues.