Lintao Dan, Tian Fu, Yuhao Sun, Xixian Ruan, Shiyuan Lu, Jie Chen, Xiaoyan Wang
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Outcomes of interest were overall cardiovascular disease and all-cause mortality. Cox proportional hazard models were used to estimate the hazard ratios and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>During a mean (SD) follow-up of 10.1 (1.7) years, we documented 205 cardiovascular events and 133 deaths. Compared to non-consumers, those consuming sugar-sweetened beverages more than 1 unit/day (reported in glasses/cans/250 ml/cartons) were associated with 64% (95% CI: 5-155, <i>p</i> = 0.030) and 97% (95% CI: 16-233, <i>p</i> = 0.012) increased risk of cardiovascular disease and all-cause mortality, respectively. We also observed a 78% (95% CI: 3-205, <i>p</i> = 0.038) increased risk of cardiovascular disease in participants who consumed artificially sweetened beverages more than 1 unit/day when compared with non-consumers. We did not observe significant associations between natural juice consumption and the two outcomes in IBD.</p><p><strong>Conclusion: </strong>Higher sugar- and artificially sweetened beverage consumption were associated with adverse cardiovascular and mortality outcomes in IBD. 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引用次数: 0
摘要
背景:在一般人群中，饮料消费被发现与心血管疾病和死亡率有关。然而，尚不清楚这种关联是否仍然存在于炎症性肠病(IBD)患者中。目的:研究含糖饮料、人工加糖饮料和天然果汁与IBD患者心血管疾病和全因死亡率的关系。设计:前瞻性队列研究。方法:我们在英国生物银行纳入了1981例IBD患者。使用经过验证的24小时饮食召回来测量饮料的消费量。我们感兴趣的结局是总体心血管疾病和全因死亡率。采用Cox比例风险模型估计风险比和95%置信区间(ci)。结果:在10.1(1.7)年的平均(SD)随访期间，我们记录了205例心血管事件和133例死亡。与非消费者相比，每天饮用含糖饮料超过1单位(以玻璃杯/罐装/250毫升/纸盒为单位)的人患心血管疾病和全因死亡率的风险分别增加64% (95% CI: 5-155, p = 0.030)和97% (95% CI: 16-233, p = 0.012)。我们还观察到，与非消费者相比，每天饮用人工加糖饮料超过1单位的参与者患心血管疾病的风险增加78% (95% CI: 3-205, p = 0.038)。我们没有观察到饮用天然果汁与IBD两种结果之间的显著关联。结论:高糖和人工加糖饮料的摄入与IBD患者不良的心血管和死亡率结果相关。这些探索性结果与一般人群中的证据一致，并强调了IBD患者饮食管理的重要性。
Associations of sugar-sweetened beverages, artificially sweetened beverages, and natural juices with cardiovascular disease and all-cause mortality in individuals with inflammatory bowel disease in a prospective cohort study.
Background: Beverage consumption was found to be associated with cardiovascular disease and mortality in the general population. However, it is unclear whether this association still exists in individuals with inflammatory bowel disease (IBD).
Objectives: To investigate the associations of sugar-sweetened beverages, artificially sweetened beverages, and natural juices with cardiovascular disease and all-cause mortality among individuals with IBD.
Design: Prospective cohort study.
Methods: We included 1981 participants with IBD in the UK Biobank. Consumption of beverages was measured using a validated 24-h diet recall. Outcomes of interest were overall cardiovascular disease and all-cause mortality. Cox proportional hazard models were used to estimate the hazard ratios and 95% confidence intervals (CIs).
Results: During a mean (SD) follow-up of 10.1 (1.7) years, we documented 205 cardiovascular events and 133 deaths. Compared to non-consumers, those consuming sugar-sweetened beverages more than 1 unit/day (reported in glasses/cans/250 ml/cartons) were associated with 64% (95% CI: 5-155, p = 0.030) and 97% (95% CI: 16-233, p = 0.012) increased risk of cardiovascular disease and all-cause mortality, respectively. We also observed a 78% (95% CI: 3-205, p = 0.038) increased risk of cardiovascular disease in participants who consumed artificially sweetened beverages more than 1 unit/day when compared with non-consumers. We did not observe significant associations between natural juice consumption and the two outcomes in IBD.
Conclusion: Higher sugar- and artificially sweetened beverage consumption were associated with adverse cardiovascular and mortality outcomes in IBD. These exploratory results were consistent with the evidence in the general population and highlighted the importance of diet management in individuals with IBD.
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