Ege Anıl Uçar, Mehmet Batuhan Karakuş, Mustafa Güldan, Selin Merve Şahin, Uluman Şişman, Arzu Baygül, Sinem Ezgi Gülmez
{"title":"ANTIBACDUS-PAN：12 个月内 COVID-19 大流行之前和期间成人患者的抗菌药物使用情况：一项三级医院药物流行病学研究。","authors":"Ege Anıl Uçar, Mehmet Batuhan Karakuş, Mustafa Güldan, Selin Merve Şahin, Uluman Şişman, Arzu Baygül, Sinem Ezgi Gülmez","doi":"10.36519/idcm.2022.100","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Irrational use of antibacterials is a concern during the COVID-19 pandemic. Hospital pharmacoepidemiology studies are important for evaluating the rational use of medicines, especially antibacterials, during pandemics. Defined daily doses (DDD) and drug utilization 90% (DU90%) are established methods for the evaluation of drug utilization. We aimed to evaluate antibacterial utilization in a tertiary hospital setting at Koç University Hospital (KUH).</p><p><strong>Materials and methods: </strong>This cross-sectional, descriptive study was retrospectively conducted with data extracted from KUH Inpatient Electronic Order System (CP) and was carried out for a period of one year. Antibacterial utilization of adult (aged ≥ 18 years) inpatients, who were prescribed at least one type of systemic antibacterial (ATC code J01), was evaluated using the recommended parameter DDD/100 admission and compared between 6 months before COVID-19 and during COVID-19 periods. March 11, 2020, the very first COVID-19 diagnosed case in Turkey, was set as the cutoff date of the 6-month period for the selection of the compared antibacterials using the DU90% method.</p><p><strong>Results: </strong>Finally, 3280 of 5942 and 2605 of 4942 prescriptions for pre-COVID-19 and COVID-19 periods were included, respectively. Antibacterial utilization according to DDD/100 admissions increased from 193.96 to 201.26 DDD/100 admissions after the initiation of COVID-19 pandemic. The most utilized antibacterials were piperacillin and enzyme inhibitors in pre-COVID-19 period, whereas meropenem was utilized the most during COVID-19 period. Azithromycin utilization increased by 656.24%, whereas clarithromycin utilization decreased by 52.12%. Antibacterials were utilized most in general surgery department, with an increase of 17.57%.</p><p><strong>Conclusion: </strong>There is an increase in antibacterial utilization in KUH during COVID-19 pandemic, especially reserved antibacterials, which is a concern for antibacterial resistance.</p>","PeriodicalId":41984,"journal":{"name":"JOURNAL OF FLOW VISUALIZATION AND IMAGE PROCESSING","volume":"15 1","pages":"30-39"},"PeriodicalIF":0.8000,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11022819/pdf/","citationCount":"0","resultStr":"{\"title\":\"ANTIBACDUS-PAN: Antibacterial Utilization among Adult Patients Before and During COVID-19 Pandemic within 12-Months Period: A Tertiary Hospital Pharmacoepidemiology Study.\",\"authors\":\"Ege Anıl Uçar, Mehmet Batuhan Karakuş, Mustafa Güldan, Selin Merve Şahin, Uluman Şişman, Arzu Baygül, Sinem Ezgi Gülmez\",\"doi\":\"10.36519/idcm.2022.100\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Irrational use of antibacterials is a concern during the COVID-19 pandemic. Hospital pharmacoepidemiology studies are important for evaluating the rational use of medicines, especially antibacterials, during pandemics. Defined daily doses (DDD) and drug utilization 90% (DU90%) are established methods for the evaluation of drug utilization. We aimed to evaluate antibacterial utilization in a tertiary hospital setting at Koç University Hospital (KUH).</p><p><strong>Materials and methods: </strong>This cross-sectional, descriptive study was retrospectively conducted with data extracted from KUH Inpatient Electronic Order System (CP) and was carried out for a period of one year. Antibacterial utilization of adult (aged ≥ 18 years) inpatients, who were prescribed at least one type of systemic antibacterial (ATC code J01), was evaluated using the recommended parameter DDD/100 admission and compared between 6 months before COVID-19 and during COVID-19 periods. March 11, 2020, the very first COVID-19 diagnosed case in Turkey, was set as the cutoff date of the 6-month period for the selection of the compared antibacterials using the DU90% method.</p><p><strong>Results: </strong>Finally, 3280 of 5942 and 2605 of 4942 prescriptions for pre-COVID-19 and COVID-19 periods were included, respectively. Antibacterial utilization according to DDD/100 admissions increased from 193.96 to 201.26 DDD/100 admissions after the initiation of COVID-19 pandemic. The most utilized antibacterials were piperacillin and enzyme inhibitors in pre-COVID-19 period, whereas meropenem was utilized the most during COVID-19 period. Azithromycin utilization increased by 656.24%, whereas clarithromycin utilization decreased by 52.12%. Antibacterials were utilized most in general surgery department, with an increase of 17.57%.</p><p><strong>Conclusion: </strong>There is an increase in antibacterial utilization in KUH during COVID-19 pandemic, especially reserved antibacterials, which is a concern for antibacterial resistance.</p>\",\"PeriodicalId\":41984,\"journal\":{\"name\":\"JOURNAL OF FLOW VISUALIZATION AND IMAGE PROCESSING\",\"volume\":\"15 1\",\"pages\":\"30-39\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2022-03-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11022819/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JOURNAL OF FLOW VISUALIZATION AND IMAGE PROCESSING\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36519/idcm.2022.100\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/3/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"ENGINEERING, MECHANICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JOURNAL OF FLOW VISUALIZATION AND IMAGE PROCESSING","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36519/idcm.2022.100","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/3/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ENGINEERING, MECHANICAL","Score":null,"Total":0}
ANTIBACDUS-PAN: Antibacterial Utilization among Adult Patients Before and During COVID-19 Pandemic within 12-Months Period: A Tertiary Hospital Pharmacoepidemiology Study.
Objective: Irrational use of antibacterials is a concern during the COVID-19 pandemic. Hospital pharmacoepidemiology studies are important for evaluating the rational use of medicines, especially antibacterials, during pandemics. Defined daily doses (DDD) and drug utilization 90% (DU90%) are established methods for the evaluation of drug utilization. We aimed to evaluate antibacterial utilization in a tertiary hospital setting at Koç University Hospital (KUH).
Materials and methods: This cross-sectional, descriptive study was retrospectively conducted with data extracted from KUH Inpatient Electronic Order System (CP) and was carried out for a period of one year. Antibacterial utilization of adult (aged ≥ 18 years) inpatients, who were prescribed at least one type of systemic antibacterial (ATC code J01), was evaluated using the recommended parameter DDD/100 admission and compared between 6 months before COVID-19 and during COVID-19 periods. March 11, 2020, the very first COVID-19 diagnosed case in Turkey, was set as the cutoff date of the 6-month period for the selection of the compared antibacterials using the DU90% method.
Results: Finally, 3280 of 5942 and 2605 of 4942 prescriptions for pre-COVID-19 and COVID-19 periods were included, respectively. Antibacterial utilization according to DDD/100 admissions increased from 193.96 to 201.26 DDD/100 admissions after the initiation of COVID-19 pandemic. The most utilized antibacterials were piperacillin and enzyme inhibitors in pre-COVID-19 period, whereas meropenem was utilized the most during COVID-19 period. Azithromycin utilization increased by 656.24%, whereas clarithromycin utilization decreased by 52.12%. Antibacterials were utilized most in general surgery department, with an increase of 17.57%.
Conclusion: There is an increase in antibacterial utilization in KUH during COVID-19 pandemic, especially reserved antibacterials, which is a concern for antibacterial resistance.
期刊介绍：
The Journal of Flow Visualization and Image Processing is a quarterly refereed research journal that publishes original papers to disseminate and exchange knowledge and information on the principles and applications of flow visualization techniques and related image processing algorithms. Flow visualization and quantification have emerged as powerful tools in velocity, pressure, temperature and species concentration measurements, combustion diagnostics, and process monitoring related to physical, biomedical, and engineering sciences. Measurements were initially based on lasers but have expanded to include a wider electromagnetic spectrum. Numerical simulation is a second source of data amenable to image analysis. Direct visualization in the form of high speed, high resolution imaging supplements optical measurements. A combination of flow visualization and image processing holds promise to breach the holy grail of extracting instantaneous three dimensional data in transport phenomena. Optical methods can be enlarged to cover a wide range of measurements, first by factoring in the applicable physical laws and next, by including the principle of image formation itself. These steps help in utilizing incomplete data and imperfect visualization for reconstructing a complete scenario of the transport process.[...] The journal will promote academic and industrial advancement and improvement of flow imaging techniques internationally. It seeks to convey practical information in this field covering all areas in science, technology, and medicine for engineers, scientists, and researchers in industry, academia, and government.
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