{"title":"吗啡镇痛耐受性","authors":"Anthony L. Vaccarino","doi":"10.1016/S1082-3174(99)70016-4","DOIUrl":null,"url":null,"abstract":"<div><p>There is a growing body of evidence that implicates the role of excitatory amino acids (EEAs), in particular the N-methyl-D-aspartate (NMDA) receptor, in the development of opioid tolerance. In their Focus article, Fundytus and Coderre have proposed a model of opioid tolerance that highlights the importance of metabotropic glutamate receptors (MGIuRs) in the contribution of EEAs to opioid tolerance. The authors conclude that drugs that target MGIuRs may provide a therapeutic tool for the prevention of tolerance to morphine analgesia in humans. However, although the authors provide clear evidence that MGIuRs play a critical role in the development of tolerance to morphine analgesia, we should practice caution in ascribing a single mechanism to a complex phenomenon. The aim of this Commentary is to examine some broader issues that surround tolerance to morphine analgesia to highlight the complexity of the problem.</p></div>","PeriodicalId":101001,"journal":{"name":"Pain Forum","volume":"8 1","pages":"Pages 25-28"},"PeriodicalIF":0.0000,"publicationDate":"1999-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1082-3174(99)70016-4","citationCount":"11","resultStr":"{\"title\":\"Tolerance to morphine analgesia\",\"authors\":\"Anthony L. Vaccarino\",\"doi\":\"10.1016/S1082-3174(99)70016-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>There is a growing body of evidence that implicates the role of excitatory amino acids (EEAs), in particular the N-methyl-D-aspartate (NMDA) receptor, in the development of opioid tolerance. In their Focus article, Fundytus and Coderre have proposed a model of opioid tolerance that highlights the importance of metabotropic glutamate receptors (MGIuRs) in the contribution of EEAs to opioid tolerance. The authors conclude that drugs that target MGIuRs may provide a therapeutic tool for the prevention of tolerance to morphine analgesia in humans. However, although the authors provide clear evidence that MGIuRs play a critical role in the development of tolerance to morphine analgesia, we should practice caution in ascribing a single mechanism to a complex phenomenon. The aim of this Commentary is to examine some broader issues that surround tolerance to morphine analgesia to highlight the complexity of the problem.</p></div>\",\"PeriodicalId\":101001,\"journal\":{\"name\":\"Pain Forum\",\"volume\":\"8 1\",\"pages\":\"Pages 25-28\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1999-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1082-3174(99)70016-4\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pain Forum\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1082317499700164\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pain Forum","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1082317499700164","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 11
摘要
越来越多的证据表明,兴奋性氨基酸(EEAs),特别是n -甲基- d -天冬氨酸(NMDA)受体,在阿片类药物耐受性的发展中起着重要作用。在他们的焦点文章中,Fundytus和Coderre提出了一个阿片类药物耐受性模型,强调了代谢性谷氨酸受体(MGIuRs)在EEAs对阿片类药物耐受性的贡献中的重要性。作者得出结论,针对mgiur的药物可能为预防人类对吗啡镇痛的耐受性提供一种治疗工具。然而,尽管作者提供了明确的证据表明MGIuRs在吗啡镇痛耐受的发展中起着关键作用,但我们应该谨慎地将单一机制归因于复杂现象。本评注的目的是研究围绕吗啡镇痛耐受性的一些更广泛的问题,以突出问题的复杂性。
There is a growing body of evidence that implicates the role of excitatory amino acids (EEAs), in particular the N-methyl-D-aspartate (NMDA) receptor, in the development of opioid tolerance. In their Focus article, Fundytus and Coderre have proposed a model of opioid tolerance that highlights the importance of metabotropic glutamate receptors (MGIuRs) in the contribution of EEAs to opioid tolerance. The authors conclude that drugs that target MGIuRs may provide a therapeutic tool for the prevention of tolerance to morphine analgesia in humans. However, although the authors provide clear evidence that MGIuRs play a critical role in the development of tolerance to morphine analgesia, we should practice caution in ascribing a single mechanism to a complex phenomenon. The aim of this Commentary is to examine some broader issues that surround tolerance to morphine analgesia to highlight the complexity of the problem.