醛和缩醛

Patty's Toxicology Pub Date : 2001-04-16 DOI:10.1002/0471435139.TOX073

M. Morandi, S. Maberti

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引用次数: 0

摘要

有300多种醛存在于食物、水和空气中。由于羰基碳的亲电性，特别是当邻近碳-碳双键时，醛与硫醇和胺反应形成蛋白质-蛋白质、dna -蛋白质和DNA-DNA交联。尽管它们有可能造成细胞损伤，但缺乏大量醛类物质的毒理学和暴露数据。吸入和摄入的研究表明，在动物模型中，许多醛是刺激物，可以诱发肿瘤。甲醛被怀疑是致癌物，是这些化合物中研究最广泛的。综述了饱和醛的理化性质。介绍了其毒理学和健康效应。关键词:饱和脂肪醛;甲醛;脲醛树脂;环保局;清洁空气法;调味剂;不饱和脂肪醛;卤代醛;脂肪族醛;芳香醛;杂环醛;缩醛树脂

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Aldehydes and Acetals

More than 300 aldehydes occur in foods, water, and air. Due to the electrophilicity of the carbonyl carbon, particularly when proximal to a carbon–carbon double bond, aldehydes react with thiols and amines to form protein–protein, DNA–protein, and DNA–DNA cross-links. Despite their potential for causing cell damage, toxicological and exposure data for a large number of aldehydes are lacking. Inhalation and ingestion studies have demonstrated that a number of aldehydes are irritants and can induce tumors in animal models. Formaldehyde which is a suspected carcinogen is the most widely studied of these compounds. The physicochemical properties of saturated aldehydes are summarized. Toxicological and health effects are presented. Keywords: Saturated aliphatic aldehydes; Formaldehyde; Urea-formaldehyde resins; EPA; Clean Air Act; Flavoring agents; Unsaturated aliphatic aldehydes; Halogenated aldehydes; Aliphatic dialdehydes; Aromatic aldehydes; Heterocyclic aldehydes; Acetals

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Patty's Toxicology

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