影响内分泌系统的国家化学物质清单的科学依据

Khalidya Khizbulaevna Khamidulina, E. Tarasova, I. V. Zamkova, E. V. Dorofeeva, I. N. Araslanov, Yuliya Yurevna Aniskova, A. S. Proskurina, D. N. Rabikova, Michail Leonidovich Lastovetskiy, Andrey Konstantinovich Nazarenko
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摘要

介绍。当今世界,与诱变剂、致癌物、生殖毒性物质一样,影响内分泌系统的化学物质也受到严重关注。因此,我们研究的目的是为国家内分泌干扰物清单提供科学依据。材料和方法。为了创建一个对内分泌系统有影响的物质的国家清单,为了选择候选物质,对欧盟、美国、加拿大和印度的立法和潜在内分泌干扰物清单进行了分析。所有物质均按CAS编号、应用领域和对内分泌系统的危害程度进行了分类。结果。在俄罗斯联邦流通的内分泌干扰物清单草案包括用于医药、农业、化学、食品、香水和化妆品工业的494种化学品。1A类(已知内分泌干扰物)物质19种,1B类(可能内分泌干扰物)物质193种,2类(疑似内分泌干扰物)物质250种,3类(内分泌干扰物)物质32种。结论。在俄罗斯联邦领土的各个经济领域,破坏内分泌系统的化学品被广泛使用。特别值得关注的是在香水、化妆品和食品中使用危害等级为1B的内分泌干扰物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Scientific substantiation of the national list of chemicals affecting the endocrine system
Introduction. Today in the world, along with mutagens, carcinogens, reprotoxicants, chemicals that affect the endocrine system are of serious concern. Therefore, the purpose of our research was the scientific substantiation of the national list of endocrine disruptors. Materials and methods. In order to create a national list of substances that have an effect on the endocrine system, for the selection of candidate substances, an analysis of legislation and lists of potential endocrine disruptors of the European Union, the USA, Canada, and India was made. All substances were identified by CAS numbers, areas of application and classified according to the degree of danger to the endocrine system. Results. The draft list of endocrine disruptors circulating in the Russian Federation includes 494 chemicals used in medicine, agriculture, chemical, food, perfume and cosmetic industries. There are 19 substances in class 1A (known endocrine disruptor), 193 substances in class 1B (probable endocrine disruptor), 250 substances in class 2 (suspected endocrine disruptors), and 32 substances in class 3 (endocrine disruptors). Conclusion. On the territory of the Russian Federation in various areas of the economy, chemicals that destroy the endocrine system are widely used. Of particular concern is the use of endocrine disruptors of hazard class 1B in perfumery, cosmetics and food products.
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