[适应固定应激过程中能量代谢的相位变化]。

V. Portnichenko, V. Nosar, O. Honchar, H. V. Opanasenko, I. D. Hlazyrin, I. M. Man'kovs'ka
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引用次数: 0

摘要

在应激状态下,脂质过氧化物损伤导致器官和组织发生改变,屏障功能被破坏。结果,它导致了“应激性肺”综合征,并破坏了向组织的氧气输送和缺氧。本研究旨在探讨慢性应激(每天固定6小时,持续3周)对小鼠气体交换、血糖、体温、氧化和抗氧化系统活性以及线粒体呼吸的影响。在慢性应激动力学中,确定了能量代谢的4个阶段变化。在第一阶段,发现低代谢,不稳定的氧化代谢,nad依赖性底物氧化降低,fad依赖性底物氧化显著升高,MRU低。超氧化物歧化酶(MnSOD)活性升高;这是由于谷胱甘肽过氧化物酶活性低和抗氧化系统失衡所致。7次固定后,观察到能量代谢的第二阶段转移,然后开始第三阶段(高代谢)。其特征是氧化代谢逐渐增加,nad依赖性底物氧化恢复,MRU恢复,氧化和抗氧化系统平衡优化。第四个阶段在15次固定后开始,其特征是适应性反应的发展,表现为对固定影响的能量代谢耐受性增加。结果与血液皮质酮的动态变化有关。从而发现了慢性应激过程中能量代谢重建的阶段性特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Phase changes of energy metabolism during adaptation to immobilization stress].
In stress, it was showed the organ and tissue changes associated with damage by lipid peroxides, and the disrupted barrier function. As a consequence, it was to lead to a syndrome of "stress-induced lung" and violation of oxygen delivery to the tissues and hypoxia. Purpose of the study was to investigate the dynamics of changes in gas exchange, blood glucose, body temperature, oxidant and antioxidant system activity, as well as mitochondrial respiration by Chance under the influence of chronic stress (6-hour immobilization daily for 3 weeks). It was identified 4 phase changes of energy metabolism in the dynamics of chronic stress. In the first phase, hypomethabolic, instability oxidative metabolism, decreased oxidation of NAD-dependent substrates, significant elevation of FAD-dependent substrates oxidation and low MRU were found. The activity of superoxide dismutase (MnSOD) was increased; it was occurred on a background low activity of glutathione peroxidase, and of misbalanced antioxidant system. After seven immobilizations, second phase-shift in energy metabolism, was observed, and then the third phase (hypermetabolic) started. It was characterized by gradual increase in oxidative metabolism, the restoration of oxidation of NAD-dependent substrates, MRU, as well as optimizing balance of oxidant and antioxidant systems. The fourth phase was started after 15 immobilizations, and characterized by the development of adaptive reactions expressed in increased tolerance of energy metabolism to the impact of immobilization. The results are correlated with changes in the dynamics of blood corticosterone. Thus, it was found the phase character of the energy metabolism rebuilding during the chronic stress.
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