Trandolapril

M. Papich
{"title":"Trandolapril","authors":"M. Papich","doi":"10.18578/bnf.533283865","DOIUrl":null,"url":null,"abstract":"A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, trandolapril is converted by de-esterification in the liver into its active form trandolaprilat. T randolaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. T his prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. T randolaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. Qeios · Definition, February 8, 2020","PeriodicalId":19792,"journal":{"name":"Papich Handbook of Veterinary Drugs","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Trandolapril\",\"authors\":\"M. Papich\",\"doi\":\"10.18578/bnf.533283865\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, trandolapril is converted by de-esterification in the liver into its active form trandolaprilat. T randolaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. T his prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. T randolaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. Qeios · Definition, February 8, 2020\",\"PeriodicalId\":19792,\"journal\":{\"name\":\"Papich Handbook of Veterinary Drugs\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Papich Handbook of Veterinary Drugs\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18578/bnf.533283865\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Papich Handbook of Veterinary Drugs","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18578/bnf.533283865","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

一种具有抗高血压活性的非巯基血管紧张素转换酶(ACE)抑制剂。作为前药,曲多拉普利在肝脏中通过去酯化反应转化为活性形式曲多拉普利。T随机拉普利特竞争性地结合并抑制ACE,从而阻断血管紧张素I向血管紧张素II的转化。这阻止了血管紧张素II的有效血管收缩作用,导致血管舒张。T随机普利拉也减少血管紧张素ii诱导的肾上腺皮质醛固酮分泌,从而导致钠排泄增加,随后增加水分流出。Qeios·定义,2020年2月8日
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Trandolapril
A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, trandolapril is converted by de-esterification in the liver into its active form trandolaprilat. T randolaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. T his prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. T randolaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. Qeios · Definition, February 8, 2020
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信