德国NOGGO和年龄对LACC试验后早期宫颈癌手术入路的广泛调查结果- NOGGO监视器11

R. Armbrust, F. Chen, R. Richter, Muallem Mz, J. Sehouli, A. Mustea, B. Holthaus
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引用次数: 0

摘要

目的:微创手术已成为早期宫颈癌(ECC)的标准治疗方法。然而,最近发表的“LACC”试验甚至其他试验显示,与开放式根治性子宫切除术相比,MIS的PFS和OS较差。结果引起了广泛的争论关于最佳手术入路的ECC。本调查旨在获得出版后的初步见解。方法:NOGGO和AGE对全国186个妇科肿瘤中心进行数字调查。采用SPSS进行描述性统计和t检验。结果:大多数中心在治疗ECC方面具有很高的专业知识和/或经验,并且高度了解LACC试验结果。试验质量和科学价值被评为非常好/好。然而,仍有40%的人不会改变开放手术的护理标准。容量大、参与临床试验的中心更有可能改变。结论:在最近发表的关于ECC手术入路的试验令人惊讶的结果之后,这项调查代表了一些初步的见解。似乎仍然非常需要未来的试验和对MIS组中意想不到的更坏结果的可能解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Results of a German Wide Survey by NOGGO and AGE towards Current Surgical Approach in Early Stage Cervical Cancer after the LACC Trial- NOGGO MONITOR 11
Purpose: Minimally Invasive Surgery (MIS) has become the standard approach in Early Stage Cervical Cancer (ECC). However, the recently published “LACC” trial and even others could show inferior PFS and OS of MIS compared to open radical hysterectomy. The results led to a widespread debate about the best surgical approach in ECC. The present survey aimed to get first insights after publication. Methods: NOGGO and AGE conducted a nationwide digital survey among 186 Gynecological Cancer Centers. Descriptive statistics and t-tests were performed using SPSS. Results: A majority of the centers were of high expertise and/or experience in treatment of ECC and were highly aware of the LACC trial results. Trial quality and scientific value were rated as very good/good. However, still 40% would not change the standard of care to open surgery. Centers with higher volume and participating in clinical trials were more likely to change. Conclusion: This survey represents some first insights after the surprising results of recently published trials towards the surgical approach of ECC. There still seems to be a high need of future trials and possible explanations for the unexpected worse outcomes in the MIS group.
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