在日本,腿部的区域性脂肪沉积可作为抗动脉粥样硬化的推定标志。

M. Tatsukawa, M. Kurokawa, Y. Tamari, H. Yoshimatsu, T. Sakata
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引用次数: 29

摘要

为了研究区域脂肪沉积在代谢和心血管疾病发展中的病理作用,我们使用代谢物和激素作为肥胖相关疾病的测量指标来评估区域脂肪分布。纳入的受试者是100名性别匹配的住院患者,无论其体重指数值如何,均入院接受定期医学筛查测试的异常结果的进一步检查,以及肥胖引起的并发症和肥胖治疗的检查。采用双能x线吸收仪(DEXA)分析体脂分布。脂肪分布参数分析显示,性别是影响脂肪分布与空腹血糖(FPG)、血红蛋白A1c (HbA1c)、总胆固醇(TC)或甘油三酯(TG)代谢物相关性的决定因素之一。但无论性别如何,腿干脂肪(L/Tr)和臂干脂肪(A/Tr)与全身脂肪(%总脂肪)比均呈负相关,而女性L/Tr的回归线截距值大于男性,而A/Tr的截距值小于男性。男性总脂肪百分比、L/Tr、A/Tr与FPG、TC、TG、低密度脂蛋白(LDL)、极低密度脂蛋白(VLDL)、致动脉粥样硬化指数(A.I.)显著相关,仅apoB/A1低密度脂蛋白(LDL)与L/Tr、A/Tr显著相关。这些结果表明,男性的区域脂肪分布可能不是肥胖患者代谢紊乱发展的主要决定因素。与男性区域脂肪分布不同,女性L/Tr不仅与TC、TG、LDL相关,还与FPG、HbA1c相关,尽管男性后2种葡萄糖相关参数与脂肪沉积参数均无相关性。其余女性空腹血浆胰岛素、VLDL、A.I和ApoB/A1参数与脂肪沉积的三个参数均相关,与男性相似。因此,腿部脂肪沉积与葡萄糖和脂质代谢物参数之间存在明显的负相关,尤其是在女性中。由此产生的信息提供了一种新的见解,即腿部区域脂肪沉积可作为与肥胖相关的代谢和心血管疾病的标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regional fat deposition in the legs is useful as a presumptive marker of antiatherogenesity in Japanese.
To examine the pathological role of regional fat deposition in development of metabolic and cardiovascular disorders, regional fat distribution was evaluated using metabolites and hormones as measures of obesity-related disorders. The subjects enrolled were 100 sex-matched inpatients, who were admitted, regardless of their body mass index values, for further examination of unusual results from periodic medical screening tests, and for examination of obesity-induced complications and treatment of obesity. Body fat distribution was analyzed using dual energy X-ray absorptiometry (DEXA). Analysis of parameters regarding fat distribution showed that gender was one of the determinants affecting correlation between fat distribution and metabolites of fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), total cholesterol (TC), or triglyceride (TG). However, regardless of gender, both leg trunk fat (L/Tr) and arm trunk fat (A/Tr) ratios negatively correlated with a total body fat (% total fat) ratio, whereas the intercept value of female regression line in L/Tr was greater than that in males, but not in A/Tr. Percentage total fat, L/Tr, and A/Tr in males correlated significantly with FPG, TC, TG, low-density lipoprotein (LDL), very low density lipoprotein (VLDL), atherogenic index (A.I.), and apoB/A1 only low density lipoprotein (LDL) was significantly correlated solely to L/Tr and A/Tr. These results indicate that regional fat distribution in males may not be a major determinant for development of metabolic disorders in obese patients. Unlike male regional fat distribution, female L/Tr correlated significantly not only with TC, TG, and LDL, but also with FPG and HbA1c, although both of the latter 2 glucose-related parameters in males showed no correlation with any parameters of fat deposition. The remaining female parameters of fasting plasma insulin, VLDL, A.I., and ApoB/A1 correlated with each of the three parameters of fat deposition, as similarly shown in males. The powerful and negative correlation was thus evident, particularly in females, between leg fat deposition and parameters of glucose and lipid metabolites. The resulting information provides a novel insight that regional fat deposition at the legs is useful as a marker for metabolic and cardiovascular disorders associated with obesity.
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