2019冠状病毒病少即是多

Jingjing Xu, K. Kang, Fu Li, Dong-sheng Fei, Wei Yang, Changsong Wang, Kaijiang Yu
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引用次数: 0

摘要

世界卫生组织COVID - 19临床管理指南和美国国立卫生研究院COVID - 19治疗指南。然而,糖皮质激素对COVID - 19患者的影响存在争议。根据一项研究,[5]地塞米松组与标准护理组在死亡率、无重症监护天数或机械通气时间方面无显著差异。因此,糖皮质激素不能经常使用。最后,根据以上综述,目前不推荐免疫治疗或靶向治疗。我们需要更多针对COVID - 19的免疫治疗临床试验,以指导我们个性化使用。相反,我们认为需要做的是:适当的营养支持是COVID - 19的另一个重要治疗方法,肠内营养,越早越好;然后,抗凝治疗是必要的,以防止血栓形成。有许多研究报道,血栓预防与较低的死亡风险和较低的血栓栓塞事件累积发生率有关,特别是在高剂量的情况下此外,对患者出现的发热、咳嗽等症状,应采取对症治疗。供氧:俯卧位,潮气量通气(<10 ml/kg)。最后但并非最不重要的是,器官支持,如呼吸机,持续肾脏替代疗法和体外膜氧合正在临床试验中,结果是预期的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Less is more in Corona Virus Disease 2019
both the World Health Organization guidance for the clinical management of COVID‐19 and the National Institutes of Health COVID‐19 treatment guidelines. However, the effect of glucocorticoid on patients with COVID‐19 is controversial. According to a study,[5] dexamethasone group VS standard care group was no significant difference in mortality, intensive care unit‐free days, or mechanical ventilation duration. Hence, glucocorticoid is not to use regularly. Finally, according to the above review, immunotherapy or targeted therapy is not recommended for now. We need more clinical trials for immunotherapy in COVID‐19 to guide us to personalized use. Contrary, what we think needs to be done: Proper nutritional support is another important therapy for COVID‐19, enteral nutrition, the earlier the better; then, anticoagulant therapy is necessary to prevent thrombosis. There are lots of studies that reported that thromboprophylaxis was associated with a lower risk of death and a lower cumulative incidence of thromboembolic events, especially with high doses.[6] In addition, the fever, cough, and other symptoms of the patient should be treated by symptomatic treatment. For oxygen, perform in the prone position and tidal volume for ventilation (<10 ml/kg). Last but not least, organ support such as a ventilator, continuous renal replacement therapy, and extracorporeal membrane oxygenation are in clinical trials,[1] the results are being expected.
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