作为人类心脏电生理模型的斑马鱼心脏

IF 3.3 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
M. Vornanen, M. Hassinen
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引用次数: 113

摘要

斑马鱼(Danio rerio)已成为人类心脏疾病和包括心律失常在内的药理学的流行模型及其电生理基础。值得注意的是,斑马鱼的心脏动作电位表型与人类相似,都有一个较长的平台期。此外,在斑马鱼和人类的心脏中,主要的内向和外向电流系统在性质上是相似的。然而,人类和斑马鱼心脏的离子电流组成也存在显著差异,人类和斑马鱼心脏离子电流的分子基础和药理特性在几个方面存在差异。在斑马鱼和人类中,心脏离子电流可能由非同源基因产生,一些离子通道的同源基因产物在斑马鱼心脏中表达。为了合理利用斑马鱼心脏作为人类心脏电生理模型,需要对心脏离子通道的分子基础、心脏离子电流的调控和药物敏感性进行更多的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Zebrafish heart as a model for human cardiac electrophysiology
ABSTRACT The zebrafish (Danio rerio) has become a popular model for human cardiac diseases and pharmacology including cardiac arrhythmias and its electrophysiological basis. Notably, the phenotype of zebrafish cardiac action potential is similar to the human cardiac action potential in that both have a long plateau phase. Also the major inward and outward current systems are qualitatively similar in zebrafish and human hearts. However, there are also significant differences in ionic current composition between human and zebrafish hearts, and the molecular basis and pharmacological properties of human and zebrafish cardiac ionic currents differ in several ways. Cardiac ionic currents may be produced by non-orthologous genes in zebrafish and humans, and paralogous gene products of some ion channels are expressed in the zebrafish heart. More research on molecular basis of cardiac ion channels, and regulation and drug sensitivity of the cardiac ionic currents are needed to enable rational use of the zebrafish heart as an electrophysiological model for the human heart.
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来源期刊
Channels
Channels 生物-生化与分子生物学
CiteScore
5.90
自引率
0.00%
发文量
21
审稿时长
6-12 weeks
期刊介绍: Channels is an open access journal for all aspects of ion channel research. The journal publishes high quality papers that shed new light on ion channel and ion transporter/exchanger function, structure, biophysics, pharmacology, and regulation in health and disease. Channels welcomes interdisciplinary approaches that address ion channel physiology in areas such as neuroscience, cardiovascular sciences, cancer research, endocrinology, and gastroenterology. Our aim is to foster communication among the ion channel and transporter communities and facilitate the advancement of the field.
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