晚期同种异体肝移植功能障碍对肝移植受者身体活动的影响

Yulia Malinovskaya, K. Kokina, Y. Moysyuk, O. Sumtsova
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摘要

介绍。肝移植恢复了患者的身体和社会生活,并提高了生活质量。肝受体低体力活动的患病率以及晚期同种异体肝移植功能障碍对其的影响尚不清楚。肝移植可促进患者恢复正常的身体和社会活动,提高生活质量。然而,肝脏受体普遍缺乏运动,以及晚期异体移植物功能障碍对其的影响,这是肥胖和心血管疾病的危险因素,需要进一步研究。该研究的目的是确定晚期同种异体肝移植功能障碍是否影响受体的身体活动。材料和方法。该研究包括87名接受肝脏移植的患者。我们测量了人体测量参数、身体表现(SPPB、LFI、6分钟步行测试)、平均每天步数。如果转氨酶和/或淤胆酶升高或肝衰竭在移植后3个月后被诊断为晚期异体肝移植功能障碍,则确定晚期异体肝移植功能障碍。提供活动追踪器来评估身体活动。中位年龄54岁[45;61],其中33%为男性。中位随访时间为36个月[16;64]。平均步数的中位数为每天5.9[4.1;8.7]千。60.5%的接受者久坐不动且运动量低,24.4%的接受者稍微运动,15.1%的接受者运动。同种异体肝移植功能障碍患者的平均步数明显低于肝功能正常患者:4.1万步[2.6;5.3]比6.8万步[4.2;9.4],p=0.003,尽管在体力活动测试结果上没有差异。晚期异体肝移植功能不全时,体力活动减少;60.5%的肝受体在没有病理性运动限制的情况下,有久坐和低运动量的生活方式。活动追踪器可以识别需要额外检查或体育锻炼的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The impact of late liver allograft dysfunction on physical activity of liver transplant recipients
Introduction. Liver transplantation restores patients' physical and social life, and its quality. The prevalence of low physical activity in liver recipients is unknown as well as the impact of late liver allograft dysfunction on it. Liver transplantation enhances patient's return to the usual physical and social activity and improves the quality of life. However, the prevalence of low physical activity among liver recipients and the impact of the late allograft dysfunction on it, which is a risk factor for obesity and cardiovascular diseases, require studying.The aim of the study was to identify whether the late liver allograft dysfunction influences the physical activity of recipients.Material and methods. The study included 87 liver recipients. We measured anthropometric parameters, physical performance (SPPB, LFI, 6-min walk test), mean step count per day. Late liver allograft dysfunction was determined if elevated transaminases and/or cholestatic enzymes or hepatic failure have been diagnosed later than 3 months posttransplant. Activity trackers were provided to assess physical activity.Results. Median age was 54 years [45;61], 33% were men. The median follow-up period was 36 months [16;64]. The median of the average steps count was 5.9 [4.1;8.7] thousand per day. 60.5% of recipients were sedentary and low active, 24.4% were somewhat active, 15.1% were active. In cases of liver allograft dysfunction, the mean step count was significantly lower than in patients with normal liver function: 4.1 thousand [2.6;5.3] versus 6.8 thousand [4.2;9.4], p=0.003, despite no differences in the physical activity test results.Conclusion. In case of a late liver allograft dysfunction, the physical activity can decrease; 60.5% of liver recipients, in the absence of pathological restriction of movement, have a sedentary and low active lifestyle. Activity trackers may allow identifying patients who need additional check-up or physical training.
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