移动中的甘氨酸受体

Science's STKE Pub Date : 2003-10-21 DOI:10.1126/scisignal.2052003tw416

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摘要

半导体量子点(QDs)最近作为探针出现，具有彻底改变荧光成像的潜力。Dahan等人现在已经在活培养的脊髓神经元中检测到单个qd标记的甘氨酸受体。通过结合体内监测和事后电镜分析，随着时间的推移监测受体的动态，并直接观察受体进入突触的情况。M. Dahan, S. l vi, C. Luccardini, P. Rostaing, B. Riveau, A. Triller，单量子点跟踪研究甘氨酸受体的扩散动力学。科学302,442-445(2003)。【摘要】【全文】

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Glycine Receptors On the Move

Semiconductor quantum dots (QDs) have recently emerged as probes with the potential to revolutionize fluorescence imaging. Dahan et al. have now detected single QD-tagged glycine receptors in living cultured spinal neurons. By combining in vivo monitoring and post hoc electron microscopic analysis, the dynamics of receptors was monitored over time and the entry of a receptor into the synapse was directly observed. M. Dahan, S. Lévi, C. Luccardini, P. Rostaing, B. Riveau, A. Triller, Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking. Science 302, 442-445 (2003). [Abstract] [Full Text]

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