芦荟胶凝胶的药物技术开发及理化稳定性评价

K. C. Maciel, J. T. Sousa, Bianca Bernado Silva, B. M. silva, S. Tavares, Ellison Neves de Lima, C. Sousa
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引用次数: 0

摘要

背景:芦荟是一种药用植物,发现于热带地区,俗称鼻涕虫。它有药用和美容的特性。本工作旨在开发一种以芦荟为基础的具有美容作用的毛细管凝胶。材料与方法:对卡波姆、丙二醇和对羟基苯甲酸甲酯进行了定性和定量分析,确定了最佳配方。这些样品一式三份,储存在三种不同的条件下:温室、冰箱和室温,在那里它们被提交给测试。所得数据用于评价其感官和物理化学特性。结果:从感官特征得到的结果在颜色、气味和外观上表现出变化和不稳定性。在相同的条件下,不同的配方表现出不同的结果。只有一种制剂经历了被认为有必要稳定其物理化学成分的重大变化。并对我们的研究给出了满意的结果。结论:在评估理化特性时,我们分析了每个样品的pH值、密度和涂抹性,配方在国家卫生监督机构(ANVISA)化妆品质量控制指南规定的范围内没有明显变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pharmacotechnical development and evaluation of the physicochemical stability of a cosmetic gel from Aloe vera mucilage
Background: Aloe vera is a medicinal plant of the family Xanthorrhoeaceae found in tropical regions, better known as slug. It has medicinal and cosmetic properties. The present work aimed to develop a gel based on Aloe vera with cosmetic action in capillary application. Materials and Methods: A qualitative and quantitative analysis of the following components was used for the development: Carbomer, propylene glycol and methylparaben in order to identify the best formulation. The samples were made in triplicate and stored in three different conditions: hothouse, refrigerator and room temperature, where they were submitted to tests. The data obtained were used to evaluate the organoleptic and physicochemical characteristics. Results: The results obtained from the organoleptic characteristics presented variations and instability in their color, odor and appearance. The formulations presented different results even the samples being exposed to the same conditions. Only one formulation underwent changes considered significant having the need for stabilization of its physicochemical constituents. And the others presented satisfactory results to our research. Conclusions: When evaluating the physico-chemical characteristics, we analyzed the pH, density and spreadability of each sample and no formulation presented significant changes where they remained within the range of values established by the quality control guide for cosmetic products of the Agencia Nacional de Vigilância Sanitaria (ANVISA).
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