轻中度COVID-19的早期多靶点治疗,特别是在非甾体抗炎药和吲哚美辛方面

SPG biomed Pub Date : 2023-03-10 DOI:10.3390/biomed3010015
S. Fazio, P. Bellavite
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引用次数: 1

摘要

最近,意大利发布了一份供全科医生在家治疗COVID-19患者使用的流程图。报告指出,由于有特定的抗病毒药物可用于高危患者,因此对SARS-CoV-2感染的早期在家治疗是可能的,而且非甾体抗炎药(NSAIDs)在对抗该病毒方面具有重要作用。因此,在不能使用抗病毒药物治疗的病例中,使用非甾体抗炎药不仅是合理的,而且是有效的。自大流行开始以来,这些看似简单的概念一直在意大利应用,这些医生属于意大利团体,这些团体是在意大利卫生机构和政府内部组织困难的情况下创建的,目的是尽早在家中帮助COVID-19患者。然而,这一方法在很大程度上受到意大利卫生部和医疗机构的抵制,它们主要建议将扑热息痛作为症状使用,并在出现症状后的头三天采取观望方法。在本文中,我们分析了使用非甾体抗炎药的基本原理,特别是多靶点方法,包括吲哚美辛与类黄酮和低剂量阿司匹林的协同作用,作为COVID-19患者的早期家庭治疗。从一开始就应用这些简单的概念,本可以在大流行的头两年降低这种疾病的高致死率,并防止医院超负荷。从这个角度来看,仍然有必要在实验的基础上系统地处理不同治疗方法对这种病毒性疾病的比较。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early Multi-Target Treatment of Mild-to-Moderate COVID-19, Particularly in Terms of Non-Steroidal Anti-Inflammatory Drugs and Indomethacin
Recently, in Italy, a flowchart to be used by General Practitioners for the at-home treatment of patients with COVID-19, has been released. It states that early at-home treatment for SARS-CoV-2 infection is possible due to the availability of specific antiviral drugs to be used in at-risk patients, and that non-steroidal anti-inflammatory drugs (NSAIDs) have an important function in combating the virus. Therefore, the use of NSAIDs is not only rational but also effective in cases that cannot be treated using antivirals. These seemingly simple concepts have been applied in Italy since the beginning of the pandemic by doctors that belong to Italian groups created in order to help COVID-19 patients early at home, at a time of organizational difficulties within Italian health institutions and government. However, this approach was largely boycotted by both the Italian Ministry of Health and medical institutions, which mainly suggested the use of paracetamol as symptomatic, and a wait-and-watch approach for the first three days from the onset of symptoms. In this article, we analyze the rationale for the use of NSAIDs and, in particular, the multi-targeted approach including indomethacin in synergism with flavonoids and low-dose aspirin, as early at-home treatment of patients with COVID-19. Applying these simple concepts from the beginning could have reduced the high lethality of the disease during the first two years of the pandemic and prevented hospital overload. In perspective, it is still necessary to systematically address the comparison between different therapeutic approaches to this viral disease on an experimental basis.
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