COVID-19危重症患者血浆肾素浓度分析

SPG biomed Pub Date : 2021-10-07 DOI:10.3390/biomed1020008
G. Melegari, Lucia Veronesi, Jessica Maccieri, Francesco Ponzetta, Suela Osmenaj, A. Barbieri
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引用次数: 1

摘要

在一些重症监护环境中,作为器官灌注标志的血浆肾素浓度的研究表明,其升高与关键组织(特别是脓毒症患者)灌注不足之间存在显著相关性。Castillo等人提出,激活肾素-血管紧张素-醛固酮系统的非规范途径可以改善COVID-19下的心血管稳态。在第一波COVID-19期间,我们初步招募了一小批诊断为COVID-19并伴有急性呼吸窘迫综合征的重症监护病房患者。分别在治疗前24 h (T0)、72 h (T1)和1周后(T2)测定血浆肾素值。在8例患者中,我们观察到较高的血浆肾素浓度-断奶困难患者和非幸存者。这是初步的观察结果。脓毒症患者血浆肾素水平的变化是已知的,但最近对COVID-19感染等情况进行了调查,显示其与血管紧张素转换酶2受体的表达和功能相关;在不久的将来,关于其在COVID-19患者中的变化和价值的更多数据将会很有趣。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Plasma Renin Concentration in Critically Ill COVID-19 Patients
Investigations of plasma renin concentration as a marker of organ perfusion in several intensive care settings have shown a significant correlation between its increase and a lack of perfusion in critical tissues, especially in septic patients. Castillo et al. proposed that activation of the non-canonical pathway of the renin–angiotensin–aldosterone system could improve cardiovascular homeostasis under COVID-19. During the first wave of COVID-19, we preliminarily enrolled a small cohort of subjects admitted to the Intensive Care Unit with a diagnosis of COVID-19 and acute respiratory distress syndrome. Their plasma renin value was measured in the first 24 h (T0), in the following 72 h (T1), and after one week (T2). In eight patients, we observed a higher plasma renin concentration—patients with difficulty weaning and in non-survivors. This is a preliminary observation. The variation of plasma renin levels in a septic condition is known, but settings such as COVID-19 infection have recently been investigated, showing a correlation with angiotensin-converting enzyme 2 receptor expression and functionality; in the near future, it will be interesting to have more data about its variation and value in COVID-19 patients.
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