Platelet Rich Fibrin (PRF) : un nouveau biomatériau de cicatrisation

The PRF (Platelet Rich Fibrin) belongs to a new generation of platelet concentrates, with simplified modes of production and without biochemical handling of blood (heparin, EDTA, bovine thrombin, Calcium chloride…). In this fourth article, we sought to correlate the previously evaluated biology of the PRF with first established clinical results, in order to determine the potential fields of application of this biomaterial. Our reasoning is structured around four fundamental events of the cicatrisation: angiogenesis, immune control, circulating stem cells trapping and wound covering epithelialisation. Indeed, all the known clinical applications of the PRF highlight an accelerated tissue cicatrisation because of the development of an effective neovascularization, an accelerated wound closing with fast cicatricial tissue remodelling and the quasi-total absence of infectious events. This first work thus makes it possible to plan many future applications for the PRF, as well in plastic surgery as in bone surgery, provided that its real effects are evaluated in an impartial and rigorous way.