内分泌干扰物通过受体串扰作用

Environmental biotechnology Pub Date : 2016-01-01 DOI:10.14799/EBMS262

R. Kiyama

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引用次数: 10

摘要

受体，雄激素受体，甲状腺激素受体。在这里，串扰分为双向或单向，后者进一步细分为配体依赖性或非依赖性串扰。需要做更多的研究，以更清楚地了解受体串扰在内分泌干扰物诱导的细胞信号传导中的作用。这一认识将有助于开发可取代动物试验的体外和计算机分析方法。摘要

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Endocrine disruptor actions through receptor crosstalk

receptor, the androgen receptor, and the thyroid hormone receptor. Here, crosstalk is categorized as bidirectional or unidirectional, with the latter category further subdivided into ligand-dependent or –independent crosstalk. More research needs to be done to develop a clearer understanding of the involvement of receptor crosstalk in cell signaling that is induced by endocrine disruptors. This understanding will help to develop in vitro and in silico assays that can replace animal tests. ABSTRACT

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来源期刊

Environmental biotechnology

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