增强水凝胶在生物医学应用中的性能:最新成果

Hydrogels Pub Date : 2018-08-01 DOI:10.5772/INTECHOPEN.71671
Ã. Serrano-Aroca
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引用次数: 13

摘要

目前,由于水凝胶具有优异的生物相容性和吸水性能,许多水凝胶应用于许多重要的生物医学领域,如治疗递送、隐形眼镜、角膜假体、骨水泥、伤口敷料、组织工程的3D组织支架等。这些亲水性聚合物中的许多已经被美国食品和药物管理局(FDA)批准用于各种应用。然而,许多生物医学应用所需的许多潜在用途往往受到其低机械强度、抗菌和/或防污活性、生物相互作用、吸水和扩散、孔隙度、电学和/或热性能等的阻碍。因此,新型先进的水凝胶以复合材料或纳米复合材料的形式被开发为多组分体系,有望表现出优异的性能,以增加这些材料在生物医学工业中的潜在用途。尽管到目前为止取得了巨大的进步,但为了找到制造新型水凝胶的新策略来克服许多这些问题,还需要进行大量的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enhancement of Hydrogels’ Properties for Biomedical Applications: Latest Achievements
Currently, there are many hydrogels used in many important biomedical fields such as therapeutic delivery, contact lenses, corneal prosthesis, bone cements, wound dressing, 3D tissue scaffolds for tissue engineering, etc., due to their excellent biocompatibility and water sorption properties. Many of these hydrophilic polymers have been already approved by the US Food and Drug Administration (FDA) for various applications. However, many of their potential uses required for many biomedical applications often are hindered by their low mechanical strength, antimicrobial and/or antifouling activity, biological interactions, water sorption and diffusion, porosity, electrical and/or thermal properties, among others. Thus, new advanced hydrogels have been developed as mul - ticomponent systems in the form of composite or nanocomposite materials, which are expected to exhibit superior properties to increase the potential uses of these materials in the biomedical industry. Even though the great advances achieved so far, much research has to be conducted still in order to find new strategies to fabricate novel hydrogels able to overcome many of these problems.
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