{"title":"饮食干预通过ctcf介导的转录重编程保持小鼠β细胞功能","authors":"Ruo-Ran Wang, Xinyuan Qiu, Ran Pan, Hongxing Fu, Ziyin Zhang, Qintao Wang, Haide Chen, Qing-Qian Wu, Xiaowen Pan, Yanping Zhou, Pengfei Shan, Shusen Wang, Guoji Guo, Min Zheng, Lingyun Zhu, Z. Meng","doi":"10.1084/jem.20211779","DOIUrl":null,"url":null,"abstract":"Wang et al. systematically characterize the dynamic nature of β cell functional and transcriptomic adaptation along the progression of diet-induced obesity and T2D. They also identify CTCF as a key mediator of dietary intervention–induced preservation β cell function via transcriptional reprogramming.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"12","resultStr":"{\"title\":\"Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming\",\"authors\":\"Ruo-Ran Wang, Xinyuan Qiu, Ran Pan, Hongxing Fu, Ziyin Zhang, Qintao Wang, Haide Chen, Qing-Qian Wu, Xiaowen Pan, Yanping Zhou, Pengfei Shan, Shusen Wang, Guoji Guo, Min Zheng, Lingyun Zhu, Z. Meng\",\"doi\":\"10.1084/jem.20211779\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Wang et al. systematically characterize the dynamic nature of β cell functional and transcriptomic adaptation along the progression of diet-induced obesity and T2D. They also identify CTCF as a key mediator of dietary intervention–induced preservation β cell function via transcriptional reprogramming.\",\"PeriodicalId\":23015,\"journal\":{\"name\":\"The Tokushima journal of experimental medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-06-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Tokushima journal of experimental medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1084/jem.20211779\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20211779","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming
Wang et al. systematically characterize the dynamic nature of β cell functional and transcriptomic adaptation along the progression of diet-induced obesity and T2D. They also identify CTCF as a key mediator of dietary intervention–induced preservation β cell function via transcriptional reprogramming.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
