{"title":"嘌呤能在中枢神经系统中的快速传递","authors":"Alasdair J. Gibb, Fiona C. Halliday","doi":"10.1006/smns.1996.0029","DOIUrl":null,"url":null,"abstract":"<div><p>Fast synaptic transmission mediated by P<sub>2X</sub>ATP receptors is a recent discovery in the central nervous system and new information on the distribution of P<sub>2X</sub>binding sites and mRNA for P<sub>2X</sub>receptor subunits in the brain suggests that transmission mediated by ATP may be widespread. P<sub>2X</sub>ATP receptors have many functional similarities to other receptors mediating fast excitatory synaptic transmission and some significant differences. ATP release is calcium-dependent and vesicular in nature. Individual synaptic currents are small in size (around 10<!--> <!-->pA at −70<!--> <!-->mV), have a fast rise-time and decay with a time-course (decay tau<!--> <!-->=<!--> <!-->18<!--> <!-->ms at −70<!--> <!-->mV) intermediate between that of AMPA receptor-mediated synaptic currents and NMDA receptor-mediated synaptic currents. It is likely that P<sub>2X</sub>ATP receptor channels are permeable to calcium suggesting by analogy with glutamatergic transmission that purinergic transmission will participate in the regulation of calcium-dependent processes in neurones.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 4","pages":"Pages 225-232"},"PeriodicalIF":0.0000,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0029","citationCount":"38","resultStr":"{\"title\":\"Fast purinergic transmission in the central nervous system\",\"authors\":\"Alasdair J. Gibb, Fiona C. Halliday\",\"doi\":\"10.1006/smns.1996.0029\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Fast synaptic transmission mediated by P<sub>2X</sub>ATP receptors is a recent discovery in the central nervous system and new information on the distribution of P<sub>2X</sub>binding sites and mRNA for P<sub>2X</sub>receptor subunits in the brain suggests that transmission mediated by ATP may be widespread. P<sub>2X</sub>ATP receptors have many functional similarities to other receptors mediating fast excitatory synaptic transmission and some significant differences. ATP release is calcium-dependent and vesicular in nature. Individual synaptic currents are small in size (around 10<!--> <!-->pA at −70<!--> <!-->mV), have a fast rise-time and decay with a time-course (decay tau<!--> <!-->=<!--> <!-->18<!--> <!-->ms at −70<!--> <!-->mV) intermediate between that of AMPA receptor-mediated synaptic currents and NMDA receptor-mediated synaptic currents. It is likely that P<sub>2X</sub>ATP receptor channels are permeable to calcium suggesting by analogy with glutamatergic transmission that purinergic transmission will participate in the regulation of calcium-dependent processes in neurones.</p></div>\",\"PeriodicalId\":101157,\"journal\":{\"name\":\"Seminars in Neuroscience\",\"volume\":\"8 4\",\"pages\":\"Pages 225-232\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1006/smns.1996.0029\",\"citationCount\":\"38\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in Neuroscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1044576596900299\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1044576596900299","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Fast purinergic transmission in the central nervous system
Fast synaptic transmission mediated by P2XATP receptors is a recent discovery in the central nervous system and new information on the distribution of P2Xbinding sites and mRNA for P2Xreceptor subunits in the brain suggests that transmission mediated by ATP may be widespread. P2XATP receptors have many functional similarities to other receptors mediating fast excitatory synaptic transmission and some significant differences. ATP release is calcium-dependent and vesicular in nature. Individual synaptic currents are small in size (around 10 pA at −70 mV), have a fast rise-time and decay with a time-course (decay tau = 18 ms at −70 mV) intermediate between that of AMPA receptor-mediated synaptic currents and NMDA receptor-mediated synaptic currents. It is likely that P2XATP receptor channels are permeable to calcium suggesting by analogy with glutamatergic transmission that purinergic transmission will participate in the regulation of calcium-dependent processes in neurones.
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