Case Report: A Case of Methotrexate Intoxication Presenting as a Pseudo-Disseminated Herpes Zoster Infection

Background: Methotrexate intoxication is a rare and potentially fatal situation that can occur with weekly oral prescription. Case presentation: We report the case of 55-year-old women who suffered from an inadvertent methotrexate intoxication associated with daily ingestion. She was initially reported as having a disseminated herpes zoster infection. Multiple negative herpes-simplex virus cultures along with a confirmed medication misusage confirmed our diagnosis. Conclusion: This case illustrates the importance of the early recognition of methotrexate toxicity, which can have potential devastating consequences associated with daily ingestion. Healthcare providers need to be informed about the potentially devastating consequences of a dosage error and gain the tools to prevent such unfortunate events.