Articles of Significant Interest Selected from This Issue by the Editors

Shigella flexneri, the causative agent of bacillary dysentery, triggers its uptake into nonphagocytic epithelial cells, resulting in cytoskeletal rearrangements at the entry site. Upon entry, the invading bacterium escapes from the endocytic vacuole to replicate within the cytoplasm. Ehsani et al. (p. 2548 –2557) investigated the spatiotemporal dynamics of host factors at the bacterial entry site and during vacuolar escape. This work showed that (i) host factors are simultaneously recruited to the forming vacuole, (ii) host factors are sequentially dispersed from the rupturing vacuole, and (iii) the bacterial effector IpgB1 accelerates entry but not vacuolar progression or rupture.