肌肉减少症与糖尿病肾病的关系

S. Mohamed, Khalida El-Refaei, D. Mohammad
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引用次数: 0

摘要

骨骼肌减少症是骨骼肌质量的广泛性损失,并伴有力量和/或体能下降。糖尿病患者容易加速衰老过程,这些个体在早期发生肌肉减少症的风险增加。目的探讨肌肉减少症与糖尿病肾病(DN)的关系。患者与方法对60例糖尿病(DM)患者进行前瞻性横断面研究,其中DN患者19例,非肾病患者41例,健康对照40例。肌少症的诊断采用了欧洲肌少症工作组的标准。结果60例患者中,女性44例(73%),男性16例(27%),年龄31 ~ 70岁,平均±SD年龄55.4±10岁。在9例(15%)糖尿病患者中检测到肌肉减少症,而在健康对照中仅检测到1例(2.5%)患者。糖尿病肾病患者的肌肉减少率为35%,而非糖尿病肾病患者为5%。骨骼肌指数与男女BMI、女性腰围均呈正相关。结论糖尿病肾病患者肌肉减少症的发生率高于无肾病患者。男性和体重指数是糖尿病患者肌肉减少症的危险因素。
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Relationship between sarcopenia and diabetic nephropathy
Introduction Sarcopenia is a generalized loss of skeletal muscle mass combined with reduced strength and/or physical performance. Diabetic patients are prone to accelerated aging process, and these individuals are at increased risk of sarcopenia at an early age. Aim To determine the relationship between sarcopenia and diabetic nephropathy (DN). Patients and methods A prospective cross-sectional study was carried out on 60 patients with diabetes mellitus (DM), comprising 19 patients with DN and 41 patients without nephropathy, and 40 healthy controls. Sarcopenia was diagnosed using the European Working Group on Sarcopenia criteria. Results Of 60 patients, 44 (73%) were females and 16 (27%) were males, and their ages ranged from 31 to 70 years, with mean±SD age of 55.4±10 years. Sarcopenia was detected in nine (15%) patients with DM versus only one (2.5%) patient in healthy controls. The prevalence of sarcopenia was 35% in patients with DN versus 5% in those without DN. Skeletal muscle index was positively correlated with BMI in both sexes and in waist circumference in females. Conclusion The prevalence of sarcopenia was higher among diabetic patients with nephropathy than in those without nephropathy. Male sex and BMI are among the risk factors of sarcopenia in patients with DM.
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