Research progress of tumor-associated autoantibodies in screening and early diagnosis of lung cancer

Currently, there are still many problems in screening and early diagnosis of lung cancer.Noninvasive and convenient methods with high specificity and sensitivity are urgently needed to improve the efficiency of screening and early diagnosis of lung cancer.A number of studies published in recent years have shown that test of a panel of tumor-associated autoantibodies in screening and early diagnosis of lung cancer exhibits perfect specificity and fine sensitivity.In addition, combined use of a panel of autoantibodies and low dose CT can reduce false positive rate, improve specificity and positive predictive value of CT, and could be helpful in screening and early diagnosis of lung cancer.This article reviews generation mechanism, characteristics, diagnostic performance and problems of tumor-associated autoantibodies in detection of lung cancer, especially in the diagnosis of early-stage lung cancer. Key words: Autoantibodies; Early diagnosis; Lung neoplasms