非牛顿血流对动脉狭窄患者冠状动脉血流动力学的影响

Majid Abbasian, M. Shams, Ziba Valizadeh, A. Moshfegh, Ashkan Javadzadegan
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引用次数: 2

摘要

血管壁剪切应力(WSS)在狭窄动脉中的分布是一个重要的血流动力学因素,与动脉粥样硬化和血流紊乱相关。WSS取决于多种因素,如动脉的几何复杂性和弯曲程度、狭窄的严重程度和形态以及血液流变学特性。我们使用Ansys CFX软件对9个患者特异性冠状动脉模型进行血流数值模拟,这些模型的狭窄程度分为轻度、中度和重度3类。为此,我们使用9个患者特异性冠状动脉模型,包括3DQCA(定量冠状动脉造影)重建的全范围真实(生理性)狭窄,比较了两种非牛顿模型和牛顿血流粘度之间的一些数值结果。采用不可压缩和稳态形式的Navier-Stokes方程作为控制方程。血流被认为是层流,动脉壁被认为是刚性的。结果表明,WSS的大小通常随着动脉横截面积的减小而增加。尽管各动脉内不同模型的WSS大小存在差异,但三种模型的WSS沿动脉的变化趋势一致。WSS沿动脉局部峰值出现在狭窄部位,各模型相同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Non-Newtonian Blood Flow on Coronary Artery Hemodynamics in a Cohort of Patients With Stenosed Artery
Wall shear stress (WSS) distribution in stenosed arteries has been known as an important hemodynamic factor to correlate with atherosclerosis and associated disturbances in blood flow. WSS depends on various factors such as geometric complexity and tortuosity of the artery, stenosis severity and morphology as well as blood rheological properties. We conducted a numerical simulation of blood flow using Ansys CFX software in 9 patient-specific coronary artery models with 3 classes of stenosis severity: mild, moderate and severe. For this purpose, we compared some numerical results between two non-Newtonian models and Newtonian blood flow viscosity using 9 patient-specific coronary artery models including the full range of real (physiological) stenosis, reconstructed from 3DQCA (quantities coronary angiography). Incompressible and steady state form of Navier-Stokes equations were used as governing equations. Flow was considered laminar and artery walls were assumed to be rigid. Results showed that the magnitude of WSS usually increases by decreasing the cross-section area of arteries. Despite the difference in the WSS magnitude between different models in each artery, the trend of variation of WSS along the artery was the same in all three models. The local peak point of WSS along the artery occurs at the stenosis location, same for all models.
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