单鼠胚胎的片上操作与阻抗光谱传感

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-09-25 DOI:10.1109/NEMS.2014.6908795

Zhuo Li, Xinwu Xie, Weixing Chen, Weiran Liu, Ran Li

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引用次数: 0

摘要

制作了一种用于单鼠胚胎操作的微流控装置，利用微通道中的电极检测定位胚胎的阻抗谱。实验结果表明，胚胎在不同发育阶段的阻抗是不同的。正常胚胎和发育受阻胚胎的阻抗谱也不同。与传统的临床发育评价手段相比，阻抗传感是一种全新的胚胎发育评价方法，具有无标签、可量化、实时监测等优点，在临床发育状态预测中具有很大的应用潜力。

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On-chip manipulating and impedance spectroscopy sensing of single mouse embryo

A microfluidic device for single mouse embryo manipulation was fabricated and the impedance spectroscopy of the positioned embryo was detected by the electrodes in the microchannel. Experiment results showed that the impedance of embryo varies when it is at different stage. Also, healthy embryos and development-blocked embryos showed different impedance spectroscopy. Compared with the traditional means of development evaluation in clinic, sensing of impedance is a totally new method for embryo development with the benefit of label free, quantifiable, real-time monitoring and had great potential to be used in development status prediction in clinic.

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The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)

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