肝脑病患者神经元特异性烯醇化酶的测定及临床意义

中国医师进修杂志 Pub Date : 2000-08-15 DOI:10.3760/CMA.J.ISSN.1673-4904.2000.08.009

Guanghao Zhang, Q. Jin

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引用次数: 0

摘要

目的:探讨神经元特异性烯醇化酶(NSE)在肝性脑病(HE)患者中的临床意义。方法:采用ELISA法测定46例患者血清NSE。分析肝脏疾病各临床类型及HE分期的结果。结果:HE患者血清NSE水平(46.038±24.260)μg/L明显高于慢性肝炎患者(12.127±5.673)μg/L和对照组(10.196±3.237)μg/L。肝硬化、亚急性致死性肝炎和急性致死性肝炎患者血清NSE水平逐渐升高(P0.05)，且HE四期患者血清NSE水平明显高于ⅰ、ⅱ期患者。结论:HE患者血清NSE水平明显升高，肝硬化、亚急性致死性肝炎和急性致死性肝炎患者血清NSE水平逐渐升高。HE越严重，血清NSE水平越高。

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THE MEASUREMENT AND CLINICAL SIGNIFICANCE OF NEURON-SPECIFIC ENOLASE IN PATIENTS WITH HEPATOENCEPHALOPATHY

Objective:To study the clinical significance of neuron\|specific enolase (NSE) in the patients with hepatoencephalopathy(HE).Methods:The serum NSE was measured by ELISA in 46 cases.The results were analyzed in every clinical type liver disease and every stage of HE.Results:The serum NSE levels was significantly increased in the patients with HE (46.038±24.260) μg/L compared with the patients with chronic hepatitis (12.127±5.673) μg/L and control cases (10.196±3.237) μg/L.The serum NSE levels gradually increased (P0.05) in the patients with liver cirrhosis,subacute fatal hepatitis and acute fatal hepatitis,and the serum NSE levels was obviously higher in patients with the fourth stage HE than they with first and second stage.Conclusion:The serume NSE levels obviously increased in the patients with HE,and it gradually increased in the patients with liver cirrhosis,subacute fatal hepatitis and acute fatal hepatitis.The serum NSE levels were higher in the patients with more serious HE.

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来源期刊

中国医师进修杂志

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26239

期刊介绍： Chinese Journal of Postgraduates of Medicine (founded in 1978, monthly) is one of the series of journals of the Chinese Medical Association (CMA) under the supervision of the National Health Commission of the People's Republic of China, sponsored by the Chinese Medical Association (CMA) and Dalian Institute of Theoretical Medicine (DITM). It is a core journal of Chinese science and technology, a statistical source journal of Chinese scientific and technical papers, and a statistical source journal of China Academic Journal Impact Factor Annual Report. The journal adheres to the purpose of using continuing medical education and post training, highlights new theories, new knowledge, new methods and new technologies, and focuses on the combination of theory and practice, and the combination of popularisation and improvement. Main columns: Special tutorials, expert forums, clinical treatises, clinical experience, reviews and lectures, continuing medical education, teaching and research, advanced training forum, drugs and clinics, overview of progress, introduction of new technologies, imaging and clinics, lessons learnt, discussions and evaluations, case reports, discussions of clinical cases, conference proceedings, and domestic and international academic developments. The main target readers are clinical medical personnel in internal medicine, surgery, gynaecology, paediatrics and ophthalmology.