Z. Xin, Binbin Du, Yanming Wang, Shengxu Qian, Weijia Li, Yuan Gao, Miao Sun, Shifang Luan, Jinghua Yin
{"title":"表面接枝糖基两亲性化合物聚氨酯膜的血液相容性评价","authors":"Z. Xin, Binbin Du, Yanming Wang, Shengxu Qian, Weijia Li, Yuan Gao, Miao Sun, Shifang Luan, Jinghua Yin","doi":"10.4172/2155-9872.1000357","DOIUrl":null,"url":null,"abstract":"Sugar-based amphipathic compounds (BA-CnAG) were successfully prepared. Polyurethane (PU) was grafted with glycidyl methacrylate (GMA) by the means of UV irradiation, and further modified with the BA-CnAG based on the ring opening of the epoxy groups. The surface graft polymerization was confirmed by ATR-FTIR and XPS. Water contact angle, protein adsorption, and platelet adhesion measurements were used to evaluate the hydrophilicity and hemocompatibility of the films. The results demonstrated that amphiphilic surfactant-containing polymer surfaces presented protein-resistant behavior and anti-platelet adhesion after functionalization with BA-CnAG. Besides, the hemocompatibility of the modified surface deteriorated as the length of hydrophobic chain of BA-CnAG increased.","PeriodicalId":14865,"journal":{"name":"Journal of analytical and bioanalytical techniques","volume":"42 1","pages":"1-6"},"PeriodicalIF":0.0000,"publicationDate":"2017-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Hemocompatibility Evaluation of Polyurethane Film with Surface-Grafted Sugar-Based Amphipathic Compounds\",\"authors\":\"Z. Xin, Binbin Du, Yanming Wang, Shengxu Qian, Weijia Li, Yuan Gao, Miao Sun, Shifang Luan, Jinghua Yin\",\"doi\":\"10.4172/2155-9872.1000357\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Sugar-based amphipathic compounds (BA-CnAG) were successfully prepared. Polyurethane (PU) was grafted with glycidyl methacrylate (GMA) by the means of UV irradiation, and further modified with the BA-CnAG based on the ring opening of the epoxy groups. The surface graft polymerization was confirmed by ATR-FTIR and XPS. Water contact angle, protein adsorption, and platelet adhesion measurements were used to evaluate the hydrophilicity and hemocompatibility of the films. The results demonstrated that amphiphilic surfactant-containing polymer surfaces presented protein-resistant behavior and anti-platelet adhesion after functionalization with BA-CnAG. Besides, the hemocompatibility of the modified surface deteriorated as the length of hydrophobic chain of BA-CnAG increased.\",\"PeriodicalId\":14865,\"journal\":{\"name\":\"Journal of analytical and bioanalytical techniques\",\"volume\":\"42 1\",\"pages\":\"1-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-04-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of analytical and bioanalytical techniques\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4172/2155-9872.1000357\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of analytical and bioanalytical techniques","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2155-9872.1000357","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Hemocompatibility Evaluation of Polyurethane Film with Surface-Grafted Sugar-Based Amphipathic Compounds
Sugar-based amphipathic compounds (BA-CnAG) were successfully prepared. Polyurethane (PU) was grafted with glycidyl methacrylate (GMA) by the means of UV irradiation, and further modified with the BA-CnAG based on the ring opening of the epoxy groups. The surface graft polymerization was confirmed by ATR-FTIR and XPS. Water contact angle, protein adsorption, and platelet adhesion measurements were used to evaluate the hydrophilicity and hemocompatibility of the films. The results demonstrated that amphiphilic surfactant-containing polymer surfaces presented protein-resistant behavior and anti-platelet adhesion after functionalization with BA-CnAG. Besides, the hemocompatibility of the modified surface deteriorated as the length of hydrophobic chain of BA-CnAG increased.
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