益母草尿的抗血小板作用

The Chinese Pharmaceutical Journal Pub Date : 2007-09-01 DOI:10.7019/TPJ.200709.0149

Hang-Ching Lin, Sheng-Ming Pan, H. Ding, T. Chou, Wen-liang Chang

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引用次数: 10

摘要

Leonurine(1)是从益母草(Leonurus sibircus var. albiflora)的地上部分简单分离得到的。它们的结构是根据光谱证据确定的。Leonurine对凝血酶、花生四烯酸和胶原诱导的兔血小板聚集有明显的抑制作用，IC50分别为97.22 μM、31.03 μM和44.48 μM。

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Antiplatelet Effect of Leonurine from Leonurus sibiricus

Leonurine (1) was simply isolated from the aerial part of Leonurus sibircus var. albiflora. Their structures were established on the basis of spectral evidence. Leonurine showed a significant inhibited rabbit platelet aggregation induced by thrombin, arachidonic acid, and collagen in vitro with an IC50 of 97.22 μM, 31.03 μM, and 44.48 μM, respectively.

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The Chinese Pharmaceutical Journal

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