正电子发射断层扫描/计算机断层扫描(PET/CT)在肺癌分期中的作用

M. Darwish, Emam Abo Seif, M. Khaled
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引用次数: 0

摘要

肺癌是癌症相关死亡的主要原因。准确的肺癌分期对确定最佳治疗方案和预测预后具有重要意义。正电子发射断层扫描(PET)/计算机断层扫描(CT)具有PET和CT的优点,最大限度地减少了它们的局限性,是肺癌分期的潜在工具。目的探讨PET/CT在肺癌分期中的作用。患者和方法本研究于2017年11月至2019年12月期间在亚历山大卫生部Sharq El Madina医院放射诊断科附属核医学部门进行的40例病理证实的肺癌患者进行了研究,这些患者通过PET/CT进行肺癌初始分期或治疗后重新分期。PET/CT联合成像采用Siemens biograph 64 PET/CT扫描仪。(a)初始分期:PET/CT能够评估10例(25%)患者的分期,这些患者的分期不能被CECT评估。PET/CT和CECT对6例患者的分期不一致。PET/CT对10例(25%)不能通过增强计算机断层扫描(CECT)评估的患者进行分期,对6例(15%)患者的分期不一致。40例(100%)患者通过PET/CT预测T分期,30例(75%)患者通过CECT预测T分期,2例(5%)患者不一致。10例(25%)患者的N分期PET/CT与CECT不一致。PET/CT检出远处转移(M) 18例(45%),CECT检出远处转移14例(35%)。(b)新辅助治疗后再分期:8例患者中有6例(75%)分期一致,2例(25%)分期不一致。结论PET/CT具有较好的局部和远处分期能力,是肺癌早期分期的重要组成部分。它在新辅助治疗后的再分期中也更可靠,更多地与残余肿瘤的功能活性有关,而不是其大小。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Role of Positron Emission Tomography/ Computed Tomography (PET/CT) in Staging of Lung Cancer
Background Lung cancer is the leading cause of cancer-related death. The accurate staging of lung cancer is important in determining the optimal treatment strategy and predicting the prognosis. Positron emission tomography (PET)/computed tomography (CT), which has the advantages of PET and CT and minimizes their limitations, is a potential tool for the staging of lung cancer. Objective This study aimed to evaluate the role of PET/CT in the staging of lung cancer. Patients and methods This study was carried out on 40 patients with pathologically confirmed lung cancer referred to the Nuclear Medicine Unit affiliated to the Department of Radiodiagnosis at Sharq El Madina Hospital, Ministry of Health, Alexandria, between November 2017 and December 2019 for initial staging of lung cancer with PET/CT or restaging after therapy. Combined PET/CT imaging was performed using the Siemens biograph 64 PET/CT scanner. Results (a) Initial staging: PET/CT was able to assess the stage of ten patients (25%), whose stage could not be assessed by CECT. Both PET/CT and CECT disagreed in the staging of six patients. PET/CT staged 10 (25%) patients that could not be assessed by contrast enhanced computed tomography (CECT) and they disagreed in staging of six patients (15%). T staging was predicted by PET/CT in the 40 patients (100%) and by CECT in 30 patients (75%), with disagreement in two patients (5%). PET/CT disagreed with CECT in N staging of 10 patients (25%). PET/CT detected distant metastasis (M) in 18 patients (45%), while CECT detected it in 14 patients (35%). (b) Restaging after neoadjuvant therapy: staging was concordant in six out of eight patients (75%) and dissimilar in two patients (25%). Conclusion PET/CT is an essential component in the initial staging of lung cancer for its better locoregional and distant staging abilities. It is also more reliable in restaging after neoadjuvant therapy, being more related to the functional activity of the residual tumor rather than its size.
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