亚急性硬化性全脑炎(SSPE):晚发性麻疹并发症- IVIG治疗失败病例

IF 0.6 Q3 Medicine

Indian Journal of Otolaryngology and Head and Neck Surgery Pub Date : 2023-08-15 DOI:10.18231/j.ijashnb.2023.013

Athira Mohan S, Anoop V Somarajan, Dhanya Dharman

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引用次数: 0

摘要

亚急性硬化性全脑炎(SSPE)以认知运动和认知功能逐渐恶化为特征。SSPE多见于有麻疹病毒感染史的个体。我们提出一个8岁的男孩谁是表现为全身性进行性虚弱，反复跌倒向一侧，多次发作癫痫，尿失禁。经联络了解，他在3岁时有麻疹病史。检查显示血清麻疹抗体滴度升高，脑电图(EEG)分析显示周期性的定型多态放电，提示SSPE。给予IVIG及其他对症治疗。然而，他有反复发作的呕吐IVIG给药后，利巴韦林引起多发性口腔病变。出院后给予丙戊酸钠，口服类固醇(强的松龙)减量治疗，THP 2mg BD, PPI和泻药。建议家长维持RT喂养150 mL，每3小时1次。一周后，他在家中病逝。

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Subacute sclerosing panencephalitis (SSPE): Late onset of measles complication - Case of IVIG treatment failure

Subacute sclerosing panencephalitis (SSPE) is characterized by gradual deterioration of cognitive motor and cognitive functions. SSPE more often occurs in individuals who had a history of measles viral infection. We present a case of 8 year old male child who was presented with generalized progressive weakness, recurrent falls to one side, multiple episodes of seizure, urinary incontinence. On liaison it was understood that he had a history of measles at the age of 3 years. Examination showed elevated serum measles antibody titer, electro-encephalogram (EEG) analysis revealed stereotyped polymorphic discharge seen periodically, suggestive of SSPE. He was treated with IVIG and other symptomatic treatment. However he had recurrent episodes of vomiting after IVIG administration, Ribavirin administration caused multiple oral lesions. Upon discharge he was given Syr. Valproate, Oral Steroid (Prednisolone) tapering therapy, THP 2 mg BD, PPI and Laxatives. Parents were advised to maintain RT feed of 150 mL, once in 3 hours. After 1 week, he succumbed to his illness at his residence.

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来源期刊

Indian Journal of Otolaryngology and Head and Neck Surgery Medicine-Otorhinolaryngology

CiteScore

0.90

自引率

0.00%

发文量

226

审稿时长

3 months

期刊介绍： Indian Journal of Otolaryngology and Head & Neck Surgery was founded as Indian Journal of Otolaryngology in 1949 as a scientific Journal published by the Association of Otolaryngologists of India and was later rechristened as IJOHNS to incorporate the changes and progress. IJOHNS, undoubtedly one of the oldest Journals in India, is the official publication of the Association of Otolaryngologists of India and is about to publish it is 67th Volume in 2015. The Journal published quarterly accepts articles in general Oto-Rhino-Laryngology and various subspecialities such as Otology, Rhinology, Laryngology and Phonosurgery, Neurotology, Head and Neck Surgery etc. The Journal acts as a window to showcase and project the clinical and research work done by Otolaryngologists community in India and around the world. It is a continued source of useful clinical information with peer review by eminent Otolaryngologists of repute in their respective fields. The Journal accepts articles pertaining to clinical reports, Clinical studies, Research articles in basic and applied Otolaryngology, short Communications, Clinical records reporting unusual presentations or lesions and new surgical techniques. The journal acts as a catalyst and mirrors the Indian Otolaryngologist’s active interests and pursuits. The Journal also invites articles from senior and experienced authors on interesting topics in Otolaryngology and allied sciences from all over the world. The print version is distributed free to about 4000 members of Association of Otolaryngologists of India and the e-Journal shortly going to make its appearance on the Springer Board can be accessed by all the members. Association of Otolaryngologists of India and M/s Springer India group have come together to co-publish IJOHNS from January 2007 and this bondage is going to provide an impetus to the Journal in terms of international presence and global exposure.