{"title":"心理或生理止痛剂:一种和解","authors":"George Singer","doi":"10.1016/0147-7552(77)90018-3","DOIUrl":null,"url":null,"abstract":"<div><p>Recently opiate receptors have been discovered in the central nervous system (CNS) which show specificity for opiate drugs as well as for a range of endogenous polypeptides. These endogenous opiates are released during stress and under those conditions have analgesic properties, also their peripheral injection leads to analgesia. In the present paper a common biochemical substrate which involves these polypeptides as an explanation of pharmacological and psychological analgesics is proposed. The evidence for this thesis is reviewed and further experimental tests are suggested.</p></div>","PeriodicalId":100157,"journal":{"name":"Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1977-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0147-7552(77)90018-3","citationCount":"4","resultStr":"{\"title\":\"Psychological or physiological analgesics: A reconciliation\",\"authors\":\"George Singer\",\"doi\":\"10.1016/0147-7552(77)90018-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Recently opiate receptors have been discovered in the central nervous system (CNS) which show specificity for opiate drugs as well as for a range of endogenous polypeptides. These endogenous opiates are released during stress and under those conditions have analgesic properties, also their peripheral injection leads to analgesia. In the present paper a common biochemical substrate which involves these polypeptides as an explanation of pharmacological and psychological analgesics is proposed. The evidence for this thesis is reviewed and further experimental tests are suggested.</p></div>\",\"PeriodicalId\":100157,\"journal\":{\"name\":\"Biobehavioral Reviews\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1977-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0147-7552(77)90018-3\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biobehavioral Reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0147755277900183\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biobehavioral Reviews","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0147755277900183","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Psychological or physiological analgesics: A reconciliation
Recently opiate receptors have been discovered in the central nervous system (CNS) which show specificity for opiate drugs as well as for a range of endogenous polypeptides. These endogenous opiates are released during stress and under those conditions have analgesic properties, also their peripheral injection leads to analgesia. In the present paper a common biochemical substrate which involves these polypeptides as an explanation of pharmacological and psychological analgesics is proposed. The evidence for this thesis is reviewed and further experimental tests are suggested.
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