心理或生理止痛剂:一种和解

George Singer
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引用次数: 4

摘要

近年来,在中枢神经系统(CNS)中发现了对阿片药物和一系列内源性多肽具有特异性的阿片受体。这些内源性阿片类药物在应激状态下释放,具有镇痛作用,同时外周注射可引起镇痛作用。在本文中,一个共同的生化底物涉及这些多肽作为解释药理学和心理镇痛提出。回顾了本论文的证据,并提出了进一步的实验验证建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Psychological or physiological analgesics: A reconciliation

Recently opiate receptors have been discovered in the central nervous system (CNS) which show specificity for opiate drugs as well as for a range of endogenous polypeptides. These endogenous opiates are released during stress and under those conditions have analgesic properties, also their peripheral injection leads to analgesia. In the present paper a common biochemical substrate which involves these polypeptides as an explanation of pharmacological and psychological analgesics is proposed. The evidence for this thesis is reviewed and further experimental tests are suggested.

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