Effect of 4 Weeks of Progressive Resistance Training on Plasma Levels of Omentin-1 and Metabolic Factors in Diabetic Male Rats

Background and Objectives Omentin-1 is a new adipokine with a potential to increase insulin sensitivity, and is associated with lipid profile. There are limited studies on the effect of exercise on the serum level of Omentin-1. The present study aims to investigate the effect of progressive resistance training (PRT) on plasma level of omentin-1 and glycemic control in diabetic male rats. Subjects and Methods In this study, 24 male Wistar rats were randomly divided into three groups: Control, diabetic, and diabetic+PRT. The training group performed a PRT program using a ladder (three days a week, for 4 weeks). Body weight, glucose level, amentin-1 level, insulin level, and lipid profile were measured. Results The PRT significantly increased plasma levels of omentin-1 and triglycerides in the diabetic + PRT group compared to the diabetic group (P=0.017). There was no significant difference in high-density lipoprotein (F=0.318, P>0.05), low-density lipoprotein (F=0.612, P>0.05) and cholesterol (F=0.049, P>0.05) levels between the study groups. Conclusion The PRT improves omentin-1 and insulin resistance in diabetic rats.