术后早期常规给予度洛西汀对腹腔镜根治性前列腺切除术后应激性尿失禁的影响

G. Sonmez, Ş. Tombul, D. Demirci, N. Baydilli, T. Demirtas, S. Arman, A. Demirtas
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引用次数: 1

摘要

前列腺切除术后应激性尿失禁(PPI)是根治性前列腺切除术患者的重要健康问题。度洛西汀是一种常见的药物,在大多数国家用于非适应症的PPI。在本研究中,我们旨在评估度洛西汀在腹腔镜根治性前列腺切除术(LRP)患者术后早期给予PPI的预防作用。回顾性研究包括209例接受LRP的患者。将患者分为两组:第一组(n=96)在术后早期开始盆底运动(PFE) +度洛西汀治疗并持续12周,第二组(n=113)术后仅进行PFE治疗12周。排除标准为:有膀胱神经肌肉功能障碍史、前列腺切除术后急尿失禁、12周内接受辅助放疗、既往行过防失禁手术、排尿后尿>100 ml。比较拔管时(基线)、术后第3、6、12周尿失禁发生率及每天湿垫次数。研究纳入209例患者,平均年龄60.68±7.16岁。基线尿失禁率I组和II组相似(29.2% vs 35.4%, p=0.338)。在12周时,尽管两组的PPI率都有所下降,但I组和II组之间没有差异(15.6%对24.8%,p=0.103)。术后早期预防性使用度洛西汀,不考虑PPI阳性,对术后早期尿失禁恢复无明显效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of routine duloxetine administration in the early postoperative period on postprostatectomy stress incontinence in patients undergoing laparoscopic radical prostatectomy
Post-prostatectomy stress incontinence (PPI) is an important health problem for patients with radical prostatectomy history. Duloxetine is a common drug, used in PPI with the out of indications in most countries. In this study, we aimed to evaluate the prophylactic effect of duloxetine administration in PPI during the early postoperative period in patients undergoing laparoscopic radical prostatectomy (LRP). The retrospective study included 209 patients who underwent LRP. Patients were divided into two groups: Group I (n=96) was initiated on pelvic floor exercises (PFE) + duloxetine in the early postoperative period and continued this regimen for a total of 12 weeks and Group II (n=113) only performed PFE for 12 weeks after surgery. Exclusion criteria were as follows: a history of neuromuscular dysfunction of bladder, post-prostatectomy urge incontinence, receiving adjuvant radiotherapy during the 12- week period, prior anti-incontinence surgery, and post-voiding urine>100 ml. The prevalence rates of urinary incontinence measured at the time of urinary catheter removal (baseline) and at weeks 3, 6, and 12 after surgery and the number of wet pads per day were compared. The study included 209 patients with a mean age of 60.68 ± 7.16 years. Baseline urinary continence rates were similar in Group I and Group II (29.2% vs. 35.4%, p=0.338). At 12 weeks, although PPI rates have decreased in both groups, there was no difference between Group I and Group II (15.6% vs. 24.8%, p=0.103). Administration of prophylactic duloxetine in the early postoperative period, which started without regard to the positivity of PPI, is not significantly effective to early postoperative urinary continence recovery.
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