竹叶提取物对四氯化碳致白化大鼠毒性的改善作用

T. Ogunmoyole, O. Afolayan, Toluwalase Ajayi, O. J. Makun
{"title":"竹叶提取物对四氯化碳致白化大鼠毒性的改善作用","authors":"T. Ogunmoyole, O. Afolayan, Toluwalase Ajayi, O. J. Makun","doi":"10.31254/phyto.2022.11404","DOIUrl":null,"url":null,"abstract":"Bambusa vulgaris has been widely utilized in folkloric medicine for the treatment several diseases. The present study evaluates the ameliorative effects of its leaves extract on carbon tetrachloride (CCl4) induced organs’ damage. This was done to provide a cost-effective and potent therapeutic option in the management of multi-organ disorders. Twenty Wistar rats were placed into five groups (I-V) of four animals each. All experimental animals, except group I were administered a single intraperitoneal dose of CCl4 (3 ml/kg b.w.). Animals in groups III and IV were treated with B. vulgaris at 200 mg/kg b.w. and 400 mg/kg b.w. respectively, group V animals received 100 mg/kg b.w. silymarin after initial exposure, while group II animals were left untreated after initial exposure to CCl4. Specific markers of liver, kidney and heart injury such as alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), catalase, glutathione peroxidase, urea, creatinine, bilirubin and cytokines were assayed in the serum and tissue homogenates. Results indicate that carbon tetrachloride caused a significant increase in the serum level of AST, ALP, ALT, LDH as well as bilirubin, urea and inflammatory cytokines relative to control. On the other hand, activity of glutathione peroxidase and catalase were diminished following exposure to CCl4. However, treatment with the B. vulgaris extract restored to all deranged biochemical indices to values comparable with animals treated with silymarin. Histopathological evidence lends credence to the ameliorative potential of B. vulgaris leaf extract on damaged liver, heart and kidney. Hence, B. vulgaris can be considered a viable therapeutic agent for the management/treatment of renal, cardiac and hepatic diseases.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"47 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ameliorative Potentials of Bambusa vulgaris Leaf Extract on Carbon tetrachloride Induced Toxicity in Albino Rats\",\"authors\":\"T. Ogunmoyole, O. Afolayan, Toluwalase Ajayi, O. J. Makun\",\"doi\":\"10.31254/phyto.2022.11404\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Bambusa vulgaris has been widely utilized in folkloric medicine for the treatment several diseases. The present study evaluates the ameliorative effects of its leaves extract on carbon tetrachloride (CCl4) induced organs’ damage. This was done to provide a cost-effective and potent therapeutic option in the management of multi-organ disorders. Twenty Wistar rats were placed into five groups (I-V) of four animals each. All experimental animals, except group I were administered a single intraperitoneal dose of CCl4 (3 ml/kg b.w.). Animals in groups III and IV were treated with B. vulgaris at 200 mg/kg b.w. and 400 mg/kg b.w. respectively, group V animals received 100 mg/kg b.w. silymarin after initial exposure, while group II animals were left untreated after initial exposure to CCl4. Specific markers of liver, kidney and heart injury such as alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), catalase, glutathione peroxidase, urea, creatinine, bilirubin and cytokines were assayed in the serum and tissue homogenates. Results indicate that carbon tetrachloride caused a significant increase in the serum level of AST, ALP, ALT, LDH as well as bilirubin, urea and inflammatory cytokines relative to control. On the other hand, activity of glutathione peroxidase and catalase were diminished following exposure to CCl4. However, treatment with the B. vulgaris extract restored to all deranged biochemical indices to values comparable with animals treated with silymarin. Histopathological evidence lends credence to the ameliorative potential of B. vulgaris leaf extract on damaged liver, heart and kidney. Hence, B. vulgaris can be considered a viable therapeutic agent for the management/treatment of renal, cardiac and hepatic diseases.\",\"PeriodicalId\":22851,\"journal\":{\"name\":\"The Journal of Phytopharmacology\",\"volume\":\"47 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Phytopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31254/phyto.2022.11404\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Phytopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31254/phyto.2022.11404","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

竹在民间医学中被广泛用于治疗多种疾病。本研究评价了其叶提取物对四氯化碳(CCl4)诱导的器官损伤的改善作用。这样做是为了在多器官疾病的管理中提供一种具有成本效益和有效的治疗选择。20只Wistar大鼠分为5组(I-V),每组4只。除ⅰ组外,其余实验动物均单次腹腔注射CCl4 (3 ml/kg b.w.)。III组和IV组分别以200 mg/kg b.w.和400 mg/kg b.w.给药,V组初始暴露后给药水飞蓟素100 mg/kg b.w., II组初始暴露后不给药。血清和组织匀浆检测肝、肾、心损伤特异性标志物丙氨酸转氨酶(ALT)、碱性磷酸酶(ALP)、乳酸脱氢酶(LDH)、天冬氨酸转氨酶(AST)、过氧化氢酶、谷胱甘肽过氧化物酶、尿素、肌酐、胆红素和细胞因子。结果表明,与对照组相比,四氯化碳使血清AST、ALP、ALT、LDH水平以及胆红素、尿素和炎性细胞因子水平显著升高。另一方面,暴露于CCl4后,谷胱甘肽过氧化物酶和过氧化氢酶的活性降低。然而,用水飞蓟提取物处理后,动物的所有生化指标恢复到与水飞蓟素处理相当的水平。组织病理学证据证实了草叶提取物对肝、心、肾损伤的改善作用。因此,寻常B.可以被认为是一种可行的治疗药物,用于管理/治疗肾脏、心脏和肝脏疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ameliorative Potentials of Bambusa vulgaris Leaf Extract on Carbon tetrachloride Induced Toxicity in Albino Rats
Bambusa vulgaris has been widely utilized in folkloric medicine for the treatment several diseases. The present study evaluates the ameliorative effects of its leaves extract on carbon tetrachloride (CCl4) induced organs’ damage. This was done to provide a cost-effective and potent therapeutic option in the management of multi-organ disorders. Twenty Wistar rats were placed into five groups (I-V) of four animals each. All experimental animals, except group I were administered a single intraperitoneal dose of CCl4 (3 ml/kg b.w.). Animals in groups III and IV were treated with B. vulgaris at 200 mg/kg b.w. and 400 mg/kg b.w. respectively, group V animals received 100 mg/kg b.w. silymarin after initial exposure, while group II animals were left untreated after initial exposure to CCl4. Specific markers of liver, kidney and heart injury such as alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), catalase, glutathione peroxidase, urea, creatinine, bilirubin and cytokines were assayed in the serum and tissue homogenates. Results indicate that carbon tetrachloride caused a significant increase in the serum level of AST, ALP, ALT, LDH as well as bilirubin, urea and inflammatory cytokines relative to control. On the other hand, activity of glutathione peroxidase and catalase were diminished following exposure to CCl4. However, treatment with the B. vulgaris extract restored to all deranged biochemical indices to values comparable with animals treated with silymarin. Histopathological evidence lends credence to the ameliorative potential of B. vulgaris leaf extract on damaged liver, heart and kidney. Hence, B. vulgaris can be considered a viable therapeutic agent for the management/treatment of renal, cardiac and hepatic diseases.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信