Synthesis of Substituted Quinazolines Containing Pharmacophoric Groups

Continuing research on the synthesis of biologically active quinazoline derivatives [1,2] in this report we have described the synthesis of previously unknown substituted 2-methylquinzolins and 2-[2-aryl(hetaryl)vinyl]quinazolines, which contain pharmacophore groups at different positions of the ring. Synthesis was carried out by the interaction of 2-methyl-4H-3,1-benzoxzin4-ones 1a, b with aromatic and heterocyclic amines, according to the Scheme 1.