用非生物的、序列定义的聚合物模拟DNA功能

IF 11.1 2区化学 Q1 POLYMER SCIENCE

Polymer Reviews Pub Date : 2021-12-28 DOI:10.1080/15583724.2021.2014519

S. Leguizamon, T. F. Scott

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引用次数: 3

摘要

合成化学的进步使非生物的、序列定义的聚合物能够模仿曾经只属于DNA的结构和功能。事实上，庞大的可访问的主干和悬垂基团功能库使合成聚合物在新兴应用中比DNA具有优势，因为它们可以根据稳定性或性能进行定制。此外，新的测序和偶联方法已经被用来提高离散大分子的多功能性。这篇综述强调了非生物的、序列定义的聚合物在它们模仿DNA的主要功能的能力——数据存储和检索，序列特异性的双链自组装，以及新的大分子的复制和合成模板。

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Mimicking DNA Functions with Abiotic, Sequence-Defined Polymers

Abstract Advances in synthetic chemistry have enabled abiotic, sequence defined polymers to imitate the structures and functions once exclusive to DNA. Indeed, the vast library of accessible backbones and pendant-group functionalities afford synthetic polymers an advantage over DNA in emerging applications as they can be tailored for stability or performance. Moreover, novel methodologies for sequencing and conjugation have been leveraged to elevate the versatility of discrete macromolecules. This review highlights abiotic, sequence-defined polymers in their capacity to mimic the primary functions of DNA – data storage and retrieval, sequence-specific self-assembly of duplexes, and replication and synthetic templating of new macromolecules.

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来源期刊

Polymer Reviews 工程技术-高分子科学

CiteScore

24.80

自引率

0.80%

发文量

审稿时长

6 months

期刊介绍： Polymer Reviews is a reputable publication that focuses on timely issues within the field of macromolecular science and engineering. The journal features high-quality reviews that have been specifically curated by experts in the field. Topics of particular importance include biomedical applications, organic electronics and photonics, nanostructures, micro- and nano-fabrication, biological molecules (such as DNA, proteins, and carbohydrates), polymers for renewable energy and environmental applications, and interdisciplinary intersections involving polymers. The articles in Polymer Reviews fall into two main categories. Some articles offer comprehensive and expansive overviews of a particular subject, while others zero in on the author's own research and situate it within the broader scientific landscape. In both types of articles, the aim is to provide readers with valuable insights and advancements in the field of macromolecular science and engineering.